Grosu Ștefania-Alexandra, Dobre Maria, Milanesi Elena, Hinescu Mihail Eugen
Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Victor Babes National Institute of Pathology, 050096 Bucharest, Romania.
Biomedicines. 2023 Sep 14;11(9):2536. doi: 10.3390/biomedicines11092536.
Psychotic disorders are a heterogenous class of mental illness, with an intricate pathophysiology, involving genetics and environmental factors, and their interaction. The identification of accessible biomarkers in bodily systems such as blood may lead to more accurate diagnosis, and more effective treatments targeting dysfunctional pathways, and could assist in monitoring the disease evolution. This systematic review aims to highlight the dysregulated microRNAs (miRNAs) in the peripheral blood of patients with psychotic disorders. Using the PRISMA protocol, PubMed and Science Direct databases were investigated and 22 articles were included. Fifty-five different miRNAs were found differentially expressed in the blood of psychotic patients compared to controls. Seventeen miRNAs (miR-34a, miR-181b, miR-432, miR-30e, miR-21, miR-137, miR-134, miR-7, miR-92a, miR-1273d, miR-1303, miR-3064-5p, miR-3131, miR-3687, miR-4428, miR-4725-3p, and miR-5096) were dysregulated with the same trend (up- or down-regulation) in at least two studies. Of note, miR-34a and miR-181b were up-regulated in the blood of psychotic patients in seven and six studies, respectively. Moreover, the level of miR-181b in plasma was found to be positively correlated with the amelioration of negative symptoms. The panel of miRNAs identified in this review could be validated in future studies in large and well-characterized cohorts of psychotic patients.
精神障碍是一类异质性的精神疾病，其病理生理学错综复杂，涉及遗传和环境因素及其相互作用。在血液等身体系统中识别可获取的生物标志物可能会带来更准确的诊断，以及针对功能失调通路的更有效治疗，并有助于监测疾病进展。本系统综述旨在强调精神障碍患者外周血中失调的微小RNA（miRNA）。使用PRISMA方案，对PubMed和Science Direct数据库进行了检索，并纳入了22篇文章。与对照组相比，在精神疾病患者的血液中发现55种不同的miRNA表达存在差异。在至少两项研究中，17种miRNA（miR-34a、miR-181b、miR-432、miR-30e、miR-21、miR-137、miR-134、miR-7、miR-92a、miR-1273d、miR-1303、miR-3064-5p、miR-3131、miR-3687、miR-4428、miR-4725-3p和miR-5096）以相同趋势（上调或下调）失调。值得注意的是，在七项和六项研究中，精神疾病患者血液中的miR-34a和miR-181b分别上调。此外，发现血浆中miR-181b的水平与阴性症状的改善呈正相关。本综述中鉴定出的miRNA panel可在未来针对大型且特征明确的精神疾病患者队列的研究中进行验证。
