Department of Physical Therapy, China Medical University, Taichung, Taiwan.
Eur J Pharmacol. 2012 Oct 15;693(1-3):31-6. doi: 10.1016/j.ejphar.2012.07.039. Epub 2012 Aug 21.
The aim of this study was to examine whether thioxanthine-type antipsychotics (chlorprothixene and cis(z)-flupenthixol) and phenothiazine-type antipsychotics (chlorpromazine and fluphenazine) produced spinal anesthesia. Using a rat model of intrathecal injection, we evaluated spinal anesthesia of antipsychotic drugs (chlorprothixene, cis(z)-flupenthixol, chlorpromazine, and fluphenazine) and bupivacaine, a known local anesthetic. At a same dose of 2.31 μmol/kg, chlorprothixene had the most potent spinal blockades (P<0.001) and the longest duration of action (P<0.001) of motor function and nociception among those antipsychotic drugs. On the 50% effective dose (ED(50)) basis, the ranks of potencies were chlorprothixene=bupivacaine>cis(z)-flupenthixol>chlorpromazine>fluphenazine (P<0.01 for the differences) in dose-response studies. At an equianesthetic basis (ED(25), ED(50), and ED(75)), the spinal block duration caused by chlorprothixene, cis(z)-flupenthixol, chlorpromazine or fluphenazine was longer than that caused by bupivacaine (P<0.05). These results showed that chlorprothixene produced a similar potency and longer duration of spinal anesthesia than did bupivacaine, whereas several other antipsychotics produced less potency than did bupivacaine.
本研究旨在考察噻吨型抗精神病药（氯普噻吨和反式（Z）-氟奋乃静）和吩噻嗪型抗精神病药（氯丙嗪和氟奋乃静）是否产生椎管内麻醉。我们使用鞘内注射大鼠模型，评估了抗精神病药（氯普噻吨、反式（Z）-氟奋乃静、氯丙嗪和氟奋乃静）和布比卡因（一种已知的局部麻醉药）的椎管内麻醉作用。在相同剂量 2.31μmol/kg 下，氯普噻吨对运动功能和痛觉的脊髓阻滞作用最强（P<0.001），作用持续时间最长（P<0.001）。在剂量反应研究中，以半数有效剂量（ED(50)）为基础，氯普噻吨=布比卡因>反式（Z）-氟奋乃静>氯丙嗪>氟奋乃静（P<0.01）。在等麻醉剂量（ED(25)、ED(50)和 ED(75)）基础上，氯普噻吨、反式（Z）-氟奋乃静、氯丙嗪或氟奋乃静引起的脊髓阻滞时间均长于布比卡因（P<0.05）。这些结果表明，氯普噻吨产生类似的效力和更长的脊髓麻醉持续时间，而其他几种抗精神病药的效力低于布比卡因。
