微小 RNA 在乳腺癌发生和发展中的作用。
MicroRNAs in breast cancer initiation and progression.
机构信息
The Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA.
出版信息
Cell Mol Life Sci. 2012 Nov;69(21):3587-99. doi: 10.1007/s00018-012-1128-9. Epub 2012 Aug 28.
Abstract
The emerging role of microRNAs (miRNAs) in the epigenetic regulation of many cellular processes has become recognized in both basic research and translational medicine as an important way that gene expression can be fine-tuned. Breast cancer is the most frequent cancer in women, with about one million new cases diagnosed each year worldwide. Starting with the early work of miRNA profiling, more effort has now been put on functions of miRNAs in normal mammary stem cells, breast cancer initiating cells and metastatic cells, and therapy-resistant cancer cells. Future translational studies may focus on identifying miRNA signatures as cancer biomarkers and developing miRNA-based targeted therapeutics.
摘要
微 RNA（miRNAs）在许多细胞过程的表观遗传调控中的新兴作用，已在基础研究和转化医学中得到认可，是精细调控基因表达的重要方式。乳腺癌是女性最常见的癌症，全球每年约有 100 万新发病例。从 miRNA 图谱分析的早期工作开始，现在已经有更多的精力放在了 miRNA 在正常乳腺干细胞、乳腺癌起始细胞和转移细胞以及耐药癌细胞中的功能上。未来的转化研究可能集中在确定 miRNA 特征作为癌症生物标志物和开发基于 miRNA 的靶向治疗上。
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