Division of Molecular Medicine, St. John's Research Institute, Bangalore, India.
Division of Molecular Medicine, St. John's Research Institute, Bangalore, India.
Exp Cell Res. 2021 Apr 1;401(1):112518. doi: 10.1016/j.yexcr.2021.112518. Epub 2021 Feb 17.
MicroRNA mediated aberrant gene regulation has been implicated in several diseases including cancer. Recent research has highlighted the role of epigenetic modulation of the complex process of breast cancer metastasis by miRNAs. miRNAs play a crucial role in the process of metastatic evolution by facilitating alterations in the phenotype of tumor cells and the tumor microenvironment that promote this process. They act as critical determinants of the multi-step progression starting from carcinogenesis all the way to organotropism. In this review, we focus on the current understanding of the compelling role of miRNAs in breast cancer metastasis.
微小 RNA 介导的异常基因调控与包括癌症在内的多种疾病有关。最近的研究强调了 miRNA 对乳腺癌转移这一复杂过程的表观遗传调控作用。miRNA 通过促进肿瘤细胞表型和肿瘤微环境的改变，在转移进化过程中发挥关键作用，从而促进这一过程。它们是从癌变到器官趋向性的多步骤进展的关键决定因素。在这篇综述中，我们重点关注 miRNA 在乳腺癌转移中作用的最新理解。
