Cancer Institute, University of Mississippi Medical Center, Jackson, MS USA.
Cancer Biol Ther. 2013 Mar;14(3):201-12. doi: 10.4161/cbt.23296. Epub 2013 Jan 4.
MicroRNAs (miRNAs) are a class of post-transcriptional gene regulators with critical functions in normal cellular processes as well as disease processes. They are small molecules with 18~23 nucleotides in length. Since their early discovery in 1993, a large number of miRNAs have been characterized and analyzed to understand their pivotal role and their impact in a myriad of biological processes. Substantial research on miRNA highlights the involvement of these tiny RNAs in the etiopathogenesis of a variety of human diseases such as cancer, neuro-degenerative disorders, diabetes, cardiac hypertrophy and respiratory diseases. In this review, we update on recent advances of the emerging role of miRNAs in breast cancer and their clinical implications.
微小 RNA（miRNAs）是一类在后转录水平调控基因表达的分子，在正常细胞过程以及疾病过程中发挥着关键作用。它们是一类小分子，由 18 到 23 个核苷酸组成。自 1993 年首次发现以来，已经对大量的 miRNA 进行了鉴定和分析，以了解它们在众多生物学过程中的关键作用及其影响。对 miRNA 的大量研究强调了这些微小 RNA 参与了多种人类疾病的发病机制，如癌症、神经退行性疾病、糖尿病、心脏肥大和呼吸系统疾病。在这篇综述中，我们更新了 miRNA 在乳腺癌中的新兴作用及其临床意义的最新进展。
