IGF-I 受体的衰退与瓦解。
The decline and fall of the IGF-I receptor.
机构信息
Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
出版信息
J Cell Physiol. 2013 Apr;228(4):675-9. doi: 10.1002/jcp.24217.
PMID:22926508
Abstract
This review examines the effect of targeting the insulin-like growth factor 1 receptor (IGF-IR) in human cancers. The results are disappointing. The causes for the failure are discussed, as well as the possible use of the IGF-IR as a secondary target.
摘要
这篇综述探讨了针对人类癌症中胰岛素样生长因子 1 受体 (IGF-IR) 的作用。结果令人失望。讨论了失败的原因，以及 IGF-IR 作为次要靶点的可能用途。
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