Institute of Medical Microbiology, Jena University Hospital, Jena, Germany.
Antimicrob Agents Chemother. 2012 Nov;56(11):6021-5. doi: 10.1128/AAC.01484-12. Epub 2012 Aug 27.
Since cations have been reported as essential regulators of biofilm, we investigated the potential of the broad-spectrum antimicrobial and cation-chelator nitroxoline as an antibiofilm agent. Biofilm mass synthesis was reduced by up to 80% at sub-MIC nitroxoline concentrations in Pseudomonas aeruginosa, and structures formed were reticulate rather than compact. In preformed biofilms, viable cell counts were reduced by 4 logs at therapeutic concentrations. Complexation of iron and zinc was demonstrated to underlie nitroxoline's potent antibiofilm activity.
由于阳离子已被报道为生物膜的必需调节剂，我们研究了广谱抗菌剂和阳离子螯合剂硝呋太尔作为抗生物膜剂的潜力。在亚最低抑菌浓度的硝呋太尔浓度下，铜绿假单胞菌的生物膜大量合成减少了多达 80%，并且形成的结构是网状的而不是致密的。在预先形成的生物膜中，治疗浓度下的活菌计数减少了 4 个对数级。铁和锌的络合作用被证明是硝呋太尔具有强大抗生物膜活性的基础。
