Sakka Salah, Hanouneh Salah I
Department of Oral Surgery, Hama Dental School, Hama, Syria.
J Investig Clin Dent. 2013 May;4(2):113-9. doi: 10.1111/j.2041-1626.2012.00164.x. Epub 2012 Aug 27.
To investigate the effect of a 1-week postoperative course of 600 mg of ibuprofen taken four times a day on marginal bone level around oral implants.
Twenty-eight patients were allocated to the ibuprofen group (14 patients) or no-ibuprofen group (14 patients). Overall, 57 implants were inserted, 31 implants in the ibuprofen group and 26 in the no-ibuprofen group. The primary outcome measure was the change in marginal bone level around oral implants from baseline (2 weeks postplacement) to the 3- and 6-month radiographic examinations. The paralleling technique and a film holder coupled to a beam-aiming device were used to take the periapical radiographs. Measurement of changes in bone level was made using a viewing box and ×8 magnifier.
Three subjects were withdrawn from the therapy early as they did not complete the dose of ibuprofen (e.g. because of self-reported stomach upset). The mean marginal mesial bone loss from the baseline was 0.37 mm at the 3-month and 0.27 mm at the 6-month follow up for the ibuprofen group, while the corresponding values for the no-ibuprofen group were 0.15 mm and 0.08 mm. The mean marginal distal bone loss from the baseline was 0.42 mm at the 3-month and 0.2 mm at the 6-month follow up for the ibuprofen group, while the corresponding values for the no-ibuprofen group were 0.08 mm and 0.15 mm. There were no significant differences between the ibuprofen and no-ibuprofen groups when comparing the bone changes.
Administration of a short course of systemic ibuprofen for postoperative pain management following implant insertion may not have a significant effect on the marginal bone loss around oral implants in the early healing phase.
研究术后为期1周、每天服用4次600毫克布洛芬对口腔种植体周围边缘骨水平的影响。
28例患者被分为布洛芬组（14例患者）和非布洛芬组（14例患者）。总共植入了57颗种植体，布洛芬组31颗，非布洛芬组26颗。主要观察指标是从基线（种植后2周）到3个月和6个月影像学检查时口腔种植体周围边缘骨水平的变化。采用平行投照技术以及与射线定位装置相连的胶片夹拍摄根尖片。使用观片灯和×8放大镜测量骨水平的变化。
3名受试者因未完成布洛芬剂量（如因自述胃部不适）而提前退出治疗。布洛芬组在3个月随访时，从基线起平均近中边缘骨吸收为0.37毫米，6个月随访时为0.27毫米，而非布洛芬组相应的值分别为0.15毫米和0.08毫米。布洛芬组在3个月随访时，从基线起平均远中边缘骨吸收为0.42毫米，6个月随访时为0.2毫米，而非布洛芬组相应的值分别为0.08毫米和0.15毫米。比较两组的骨变化时，布洛芬组和非布洛芬组之间无显著差异。
种植术后短期内全身应用布洛芬进行疼痛管理，可能对愈合早期口腔种植体周围的边缘骨吸收无显著影响。
