Interdisciplinary Program in Molecular and Cellular Biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
J Infect Dis. 2012 Nov;206(9):1469-72. doi: 10.1093/infdis/jis515. Epub 2012 Aug 20.
Double-negative T cells (DNTCs; ie, CD3(+)CD4(-)CD8(-) T cells) play a role in limiting chronic immune activation. GB virus C (GBV-C) infection is associated with reduced T-cell activation in human immunodeficiency virus (HIV)-infected individuals. T-cell activation and DNTCs were measured in HIV-infected subjects with a nondetectable HIV load. GBV-C-viremic subjects had significantly reduced CD4(+) and CD8(+) T-cell activation (P = .003 and .034, respectively) and significantly increased DNTCs (P = .038), compared with nonviremic subjects. GBV-C load correlated with DNTC percentage (P = .004). Thus, GBV-C infection is associated with an increase in DNTCs, which may contribute to reduced immune activation during HIV infection.
双阴性 T 细胞（DNTCs；即 CD3(+)CD4(-)CD8(-)T 细胞）在限制慢性免疫激活中发挥作用。GB 病毒 C（GBV-C）感染与人类免疫缺陷病毒（HIV）感染个体中 T 细胞激活减少有关。在 HIV 载量不可检测的 HIV 感染个体中测量 T 细胞激活和 DNTCs。与非病毒血症个体相比，GBV-C 病毒血症个体的 CD4(+)和 CD8(+)T 细胞激活显著降低（分别为 P=0.003 和 P=0.034），DNTCs 显著增加（P=0.038）。GBV-C 载量与 DNTC 百分比呈正相关（P=0.004）。因此，GBV-C 感染与 DNTCs 的增加有关，这可能有助于 HIV 感染期间免疫激活减少。
