da Silva Anielly Sarana, de Campos Gabriel Montenegro, Altizani Gabriela Marengone, Barros Alice Chagas, Junqueira Dennis Maletich, Kashima Simone, Sampaio Sandra Coccuzzo, Elias Maria Carolina, Giovanetti Marta, Scrideli Carlos Alberto, Slavov Svetoslav Nanev
Blood Center of Ribeirão Preto, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14051-140, Ribeirão Preto, SP, Brazil.
Department of Childcare and Pediatrics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14049-900, Ribeirão Preto, SP, Brazil.
Virus Res. 2024 Dec;350:199479. doi: 10.1016/j.virusres.2024.199479. Epub 2024 Oct 11.
Human Pegivirus-1, typically regarded as a commensal virus, exhibits high prevalence in humans. Its frequency and impact on oncologic pediatric patients with febrile neutropenia (FN), a frequent chemotherapy complication, remains unexplored. In this study, we assessed HPgV-1 RNA prevalence in pediatric patients experiencing FN. Blood samples were collected from 30 children, 15 presenting FN and 15 comprising a control group of either undergoing treatment or in remission. Overall, HPgV-1 RNA was detected in 23.3 % of samples (26.7 % among FN patients and 20.0 % among those under treatment or in remission). Phylogenetic analysis unveiled HPgV-1 genotype 2 predominance among these samples, the most prevalent strain circulating in Brazil. Our findings prompt crucial inquiries into the role of HPgV-1 RNA in FN: is it an incidental finding and if it can influences this clinical entity? Further investigation is imperative to elucidate HPgV-1 implications in vulnerable patients cohorts, potentially informing new approaches and understanding viral dynamics in immunocompromised populations.
人佩吉病毒-1通常被视为一种共生病毒，在人类中具有很高的流行率。其在肿瘤性儿科发热性中性粒细胞减少症（FN）患者中的感染频率及其影响（FN是一种常见的化疗并发症）仍未得到探索。在本研究中，我们评估了FN儿科患者中HPgV-1 RNA的流行情况。从30名儿童中采集血样，其中15名患有FN，15名组成治疗组或缓解组作为对照组。总体而言，在23.3%的样本中检测到HPgV-1 RNA（FN患者中为26.7%，治疗组或缓解组中为20.0%）。系统发育分析揭示了这些样本中HPgV-1基因型2占主导地位，这是巴西流行最广的毒株。我们的研究结果引发了对HPgV-1 RNA在FN中作用的关键疑问：它是一个偶然发现吗？它是否会影响这一临床病症？必须进行进一步调查，以阐明HPgV-1在脆弱患者群体中的影响，这可能为新方法提供依据，并有助于理解免疫功能低下人群中的病毒动态。
