Yamada H
Department of Otorhinolaryngology, Mie University School of Medicine, Tsu.
Nihon Jibiinkoka Gakkai Kaiho. 1990 Dec;93(12):1999-2008. doi: 10.3950/jibiinkoka.93.1999.
The cloudiness of the maxillary sinus in Waters-view is 37% in patients with nasal allergy. The pathogenesis of this cloudiness has not fully understood yet; is it due to the type- I allergic reaction, or secondary maxillary sinusitis? To clarify the pathology, we studied the infiltrated cells in 37 mucosae of the maxillary sinus in which X-ray revealed an abnormal shadow. Samples were also taken from 9 antrums with chronic sinusitis, and 18 and 4 nasal mucosae form the inferior turbinate with nasal allergy and sinusitis, respectively. Each specimen were fixed with Carnoy solution and formalin, and were stained with Hematoxylin & Eosin, and with Alcian blue & Safranin. Numbers of formalin sensitive and resistant mast cells and eosinophils were determined in the epithelium, and superficial and deep layers of the lamina propria, respectively. The population of both mast cells in each compartment was not different between nasal allergy and maxillary sinusitis both in the nasal and maxillary mucosae. The number of eosinophils in the maxillary and nasal epithelial significantly increased in nasal allergy compared with sinusitis. These results suggested that type-I allergic reaction might occur in the maxillary mucosa as well as nasal mucosa in patients with nasal allergy.
在华氏位片上,鼻过敏患者上颌窦的混浊率为37%。这种混浊的发病机制尚未完全明确;是由于I型过敏反应,还是继发性上颌窦炎?为了阐明其病理情况,我们研究了37例上颌窦黏膜中浸润的细胞,这些患者的X线片显示有异常阴影。还分别从9例慢性鼻窦炎患者的上颌窦、18例鼻过敏患者的下鼻甲鼻黏膜以及4例鼻窦炎患者的下鼻甲鼻黏膜中取材。每个标本分别用卡诺伊溶液和福尔马林固定,并用苏木精-伊红染色以及阿尔辛蓝-番红染色。分别在上皮、固有层浅层和深层测定福尔马林敏感和抗性肥大细胞以及嗜酸性粒细胞的数量。在鼻黏膜和上颌窦黏膜中,鼻过敏和上颌窦炎患者各部位的肥大细胞数量均无差异。与鼻窦炎患者相比,鼻过敏患者上颌窦和鼻上皮中的嗜酸性粒细胞数量显著增加。这些结果表明,鼻过敏患者的上颌黏膜以及鼻黏膜可能都会发生I型过敏反应。