Otsuka H, Ohkubo K, Seki H, Ohnishi M, Fujikura T
Department of Otorhinolaryngology, Nippon Medical School, Dai 2 Hospital, Kanagawa, Japan.
J Laryngol Otol. 1993 May;107(5):418-22. doi: 10.1017/s002221510012331x.
The distribution and abundance of mast cells in nasal polyps, the maxillary sinus mucosa of patients with sinusitis and the turbinate mucosa of allergic rhinitis was microscopically examined using different methods of fixation. In the epithelium of the surface and the ducts of nasal polyps (n = 8), the mean number of mast cells was over 20,000 per mm3 using Mota's fixation and the increase was correlated with the epithelial thickness (P < 0.05). On the other hand those of the maxillary sinus mucosa (n = 6) and the nasal turbinate mucosa (n = 7) were less than 6,000 per mm3. In the subepithelial layer or areas deeper than the area with the glands, however, mast cell counts were less than 3,200 per mm3 in all diseases. More than 70-90 per cent of all mast cells in the epithelium of the mucosal surface and the ducts of the polyp, the maxillary sinus mucosa and nasal turbinates were formalin sensitive. Most of the mast cells in the subepithelial and deeper areas were formalin resistant in all diseases. These results suggest that conditions for mast cell growth differ between polyps and the other diseases, and that the conditions which affect mast cells may contribute to polyp development.
采用不同固定方法，通过显微镜检查鼻息肉、鼻窦炎患者上颌窦黏膜及变应性鼻炎鼻甲黏膜中肥大细胞的分布及数量。在鼻息肉（n = 8）的表面上皮及导管中，采用莫塔固定法时肥大细胞的平均数量超过每立方毫米20,000个，且其增加与上皮厚度相关（P < 0.05）。另一方面，上颌窦黏膜（n = 6）和鼻甲黏膜（n = 7）中的肥大细胞数量每立方毫米少于6,000个。然而，在所有疾病中，上皮下层或比有腺体区域更深的区域，肥大细胞计数每立方毫米少于3,200个。息肉黏膜表面上皮及导管、上颌窦黏膜和鼻甲中的所有肥大细胞中，超过70% - 90%对福尔马林敏感。在所有疾病中，上皮下及更深区域的大多数肥大细胞对福尔马林具有抗性。这些结果表明，息肉与其他疾病中肥大细胞的生长条件不同，且影响肥大细胞的条件可能促成息肉的形成。
