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电离辐射会诱导癌细胞产生干性。

Ionizing radiation induces stemness in cancer cells.

机构信息

Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.

出版信息

PLoS One. 2012;7(8):e43628. doi: 10.1371/journal.pone.0043628. Epub 2012 Aug 21.

DOI:10.1371/journal.pone.0043628
PMID:22928007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3424153/
Abstract

The cancer stem cell (CSC) model posits the presence of a small number of CSCs in the heterogeneous cancer cell population that are ultimately responsible for tumor initiation, as well as cancer recurrence and metastasis. CSCs have been isolated from a variety of human cancers and are able to generate a hierarchical and heterogeneous cancer cell population. CSCs are also resistant to conventional chemo- and radio-therapies. Here we report that ionizing radiation can induce stem cell-like properties in heterogeneous cancer cells. Exposure of non-stem cancer cells to ionizing radiation enhanced spherogenesis, and this was accompanied by upregulation of the pluripotency genes Sox2 and Oct3/4. Knockdown of Sox2 or Oct3/4 inhibited radiation-induced spherogenesis and increased cellular sensitivity to radiation. These data demonstrate that ionizing radiation can activate stemness pathways in heterogeneous cancer cells, resulting in the enrichment of a CSC subpopulation with higher resistance to radiotherapy.

摘要

癌症干细胞（CSC）模型提出，在异质性的癌细胞群体中存在少量的 CSCs，这些细胞最终负责肿瘤的起始，以及癌症的复发和转移。已经从各种人类癌症中分离出 CSCs，并且能够产生具有层次结构和异质性的癌细胞群体。CSCs 还对常规的化疗和放疗具有抗性。在这里，我们报告说，电离辐射可以在异质性癌细胞中诱导出类似于干细胞的特性。将非干细胞癌细胞暴露于电离辐射中会增强球体形成，并且这伴随着多能性基因 Sox2 和 Oct3/4 的上调。Sox2 或 Oct3/4 的敲低会抑制辐射诱导的球体形成并增加细胞对辐射的敏感性。这些数据表明，电离辐射可以激活异质性癌细胞中的干性途径，导致具有更高放射治疗抗性的 CSC 亚群富集。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/3424153/8a51dd469ea5/pone.0043628.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/3424153/3bc1fdee6e6f/pone.0043628.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/3424153/7ea3273ee54e/pone.0043628.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/3424153/6124b8793448/pone.0043628.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/3424153/5b4607ac2ba7/pone.0043628.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/3424153/8a51dd469ea5/pone.0043628.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/3424153/3bc1fdee6e6f/pone.0043628.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/3424153/7ea3273ee54e/pone.0043628.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/3424153/6124b8793448/pone.0043628.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/3424153/5b4607ac2ba7/pone.0043628.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2931/3424153/8a51dd469ea5/pone.0043628.g005.jpg

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