Smadja David M
Paris Cité University, INSERM, Innovative Therapies in Hemostasis, Paris, F-75006, France.
Hematology Department, AP-HP, Georges Pompidou European Hospital, 20 rue Leblanc, Paris, F-75015, France.
Stem Cell Rev Rep. 2024 Aug;20(6):1532-1539. doi: 10.1007/s12015-024-10736-0. Epub 2024 May 25.
The Cellular Heat Shock Response and in particular heat shock protein activation are vital stress reactions observed in both healthy and cancer cells. Hyperthermia (HT) has been proposed for several years as an advancing non-invasive cancer therapy. It selectively targets cancer cells through mechanisms influenced by temperature and temperature variations. This article delves into the impact of HT on cancer cells, especially cancer stem cells (CSCs), essential contributors to cancer recurrence and metastasis. HT has shown promise in eliminating CSCs, sensitizing them to conventional treatments and modulating the tumor microenvironment. The exploration extends to mesenchymal stem cells (MSCs), which exhibit both pro-tumorigenic and anti-tumorigenic effects. HT's potential in recruiting therapeutic MSCs for targeted delivery of antitumoral agents is also discussed. Furthermore, the article introduces Brain Thermodynamics-guided Hyperthermia (BTGH) technology, a breakthrough in temperature control and modulation of heat transfer under different conditions. This non-invasive method leverages the brain-eyelid thermal tunnel (BTT) to monitor and regulate internal brain temperature. BTGH technology, with its precision and noninvasive continuous monitoring capabilities, is under clinical investigation for applications in neurological disorders and cancer. The innovative three-phase approach involves whole-body HT, targeted brain HT, and organ-specific HT. In conclusion, the exploration of localized or whole-body HT offers promising avenues for cancer, psychiatric and neurological diseases. The ongoing clinical investigations and potential applications underscore the significance of understanding and harnessing heat's responses to enhance human health.
细胞热休克反应，尤其是热休克蛋白激活，是在健康细胞和癌细胞中都能观察到的重要应激反应。多年来，热疗（HT）一直被提议作为一种先进的非侵入性癌症治疗方法。它通过受温度和温度变化影响的机制选择性地靶向癌细胞。本文深入探讨了热疗对癌细胞，特别是癌症干细胞（CSCs）的影响，癌症干细胞是癌症复发和转移的重要促成因素。热疗在消除癌症干细胞、使其对传统治疗敏感以及调节肿瘤微环境方面已显示出前景。该探索还扩展到间充质干细胞（MSCs），其兼具促肿瘤和抗肿瘤作用。还讨论了热疗在招募治疗性间充质干细胞以靶向递送抗肿瘤药物方面的潜力。此外，本文介绍了脑热力学引导热疗（BTGH）技术，这是一种在不同条件下温度控制和热传递调节方面的突破。这种非侵入性方法利用脑 - 眼睑热通道（BTT）来监测和调节脑内温度。BTGH技术凭借其精确性和非侵入性连续监测能力，正在接受针对神经疾病和癌症应用的临床研究。创新的三相方法包括全身热疗、靶向脑部热疗和器官特异性热疗。总之，对局部或全身热疗的探索为癌症、精神疾病和神经疾病提供了有前景的途径。正在进行的临床研究和潜在应用强调了理解和利用热反应以促进人类健康的重要性。
