Singh Abha, Kamen Diane L
Division of Rheumatology and Immunology; Medical University of South Carolina; Charleston, SC USA.
Dermatoendocrinol. 2012 Apr 1;4(2):146-51. doi: 10.4161/derm.20443.
Systemic lupus erythematosus (SLE) is a complex multi-system autoimmune disease. Vitamin D deficiency has been proposed as an environmental trigger of disease onset and as a contributor to increased SLE activity. SLE patients are prone to develop vitamin D deficiency because of photosensitivity leading to sun avoidance and other sun protective measures. The impact of vitamin D on immune function previously seen in vitro and in cross-sectional studies has now been shown in prospective human studies, strengthening the evidence that there is a connection between SLE and vitamin D status. This review describes the role of vitamin D on immune function, prevalence of vitamin D deficiency in patients with SLE, identify risk factors for deficiency, describe the consequences of deficiency in SLE patients, and review current vitamin D recommendations for patients with SLE.
系统性红斑狼疮（SLE）是一种复杂的多系统自身免疫性疾病。维生素D缺乏已被认为是疾病发作的环境触发因素，也是导致SLE活动增加的一个因素。由于光敏性导致避免日晒及采取其他防晒措施，SLE患者容易出现维生素D缺乏。维生素D对免疫功能的影响此前在体外研究和横断面研究中已有所发现，现在前瞻性人体研究也证实了这一点，进一步加强了SLE与维生素D状态之间存在关联的证据。这篇综述描述了维生素D在免疫功能中的作用、SLE患者维生素D缺乏的患病率、确定缺乏的危险因素、描述SLE患者缺乏维生素D的后果，并综述目前针对SLE患者的维生素D推荐。
