Irfan Shayan A, Ali Abid A, Shabbir Naqiha, Altaf Hina, Ahmed Ali, Thamara Kunnath Jafrikh, Divya Boorle Naga Vijaya L, Miguel April K, Loh Chia Chi, Gandrakota Nikhila, Ali Baig Mirza M
Internal Medicine, Dow University of Health Sciences, Karachi, PAK.
Dow Medical College, Dr. Ruth K. M. Pfau Civil Hospital Karachi, Karachi, PAK.
Cureus. 2022 Jun 13;14(6):e25896. doi: 10.7759/cureus.25896. eCollection 2022 Jun.
This study aims to assess the role of vitamin D on systemic lupus erythematosus (SLE) patients and its effects on systemic lupus erythematosus disease activity index (SLEDAI), anti-double-stranded DNA (anti-dsDNA), C3, C4, and fatigue in patients with SLE. A systemic search was conducted using three electronic databases, i.e., PubMed/Medline, Cochrane Library, and Google Scholar. Review Manager 5.4.1 (The Cochrane Collaboration, The Nordic Cochrane Centre, Copenhagen, Denmark) was employed for statistical analysis. All studies meeting the inclusion criteria were selected. A random-effect model was used to pool the studies, and the result was reported in the standard mean difference (SMD) with its corresponding 95% confidence interval. Six randomized controlled trials were selected. Five outcomes were assessed (SLEDAI, anti-dsDNA, C3, C4, and fatigue) to evaluate the role of vitamin D in SLE patients. A significant decrease in SLEDAI (SMD = -0.85 (-1.12, -0.58); p < 0.00001; I = 42%) and a non-significant decrease in anti-dsDNA (SMD = -0.09 (-0.03, 0.12); p = 0.42; I = 0%) was noted. A significant increase in levels of C3 (SMD = 0.30 (0.09, 0.51); p = 0.006; I= 0%) and fatigue (SMD = -1.27 (-2.38, -0.16); p = 0.02; I= 56%) was noted when vitamin D was used. Insignificant difference was observed in C4 (SMD = 0.20 (-0.02, 0.41); p = 0.07; I = 0%). Vitamin D in SLE patients showed a significant decrease in SLEDAI scores and a significant increase in C3 levels. The effect of vitamin D on fatigue was inconclusive. No significant difference in anti-dsDNA and C4 levels was noted.
本研究旨在评估维生素D对系统性红斑狼疮（SLE）患者的作用及其对SLE患者的系统性红斑狼疮疾病活动指数（SLEDAI）、抗双链DNA（抗dsDNA）、C3、C4和疲劳的影响。使用三个电子数据库进行了全面检索，即PubMed/Medline、Cochrane图书馆和谷歌学术。采用Review Manager 5.4.1（丹麦哥本哈根北欧Cochrane中心Cochrane协作网）进行统计分析。选择所有符合纳入标准的研究。采用随机效应模型对研究进行汇总，并以标准均数差（SMD）及其相应的95%置信区间报告结果。选择了六项随机对照试验。评估了五个结局（SLEDAI、抗dsDNA、C3、C4和疲劳）以评估维生素D在SLE患者中的作用。结果显示SLEDAI显著降低（SMD = -0.85（-1.12，-0.58）；p < 0.00001；I² = 42%），抗dsDNA无显著降低（SMD = -0.09（-0.03，0.12）；p = 0.42；I² = 0%）。使用维生素D时，C3水平显著升高（SMD = 0.30（0.09，0.51）；p = 0.006；I² = 0%），疲劳显著增加（SMD = -1.27（-2.38，-0.16）；p = 0.02；I² = 56%）。C4无显著差异（SMD = 0.20（-0.02，0.41）；p = 0.07；I² = 0%）。SLE患者使用维生素D后SLEDAI评分显著降低，C3水平显著升高。维生素D对疲劳的影响尚无定论。抗dsDNA和C4水平无显著差异。
