Gröber Uwe, Kisters Klaus
Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.
In the past, interactions between drugs and vitamin D have received only little or no attention in the health care practices. However, since more and more drugs are used for the treatment of patients, this topic is increasingly relevant. Several drugs can interfere with the vitamin D and bone metabolism. Drugs that activate the pregnane X receptor can disrupt vitamin D metabolism and vitamin D function. Beside this, the medication oriented supplementation of vitamin D can ameliorate the pharmacologic action of some drugs, such as bisphosphonates, cytostatics and statins.
过去，药物与维生素D之间的相互作用在医疗实践中很少受到关注或根本未被关注。然而，由于越来越多的药物用于治疗患者，这个话题变得越来越重要。几种药物会干扰维生素D和骨骼代谢。激活孕烷X受体的药物会破坏维生素D代谢和维生素D功能。除此之外，以药物为导向补充维生素D可以改善某些药物的药理作用，如双膦酸盐、细胞抑制剂和他汀类药物。
