Shalaby Rania, Nabil Ghada, Ibrahim Sally, Kotb Ali Aw, Amer Hatem, Afifi Salsabeel
Oral Medicine, Oral Diagnosis and Periodontology, Faculty of Dentistry, Fayoum University, Fayoum, Egypt.
Oral medicine, Faculty of Dentistry, Cairo University, Giza, Egypt.
Clin Oral Investig. 2025 May 30;29(6):320. doi: 10.1007/s00784-025-06398-y.
Examine the responsibility of Vitamin D (VD) deficit as a risk element in the development and severity of oral lichen planus (OLP) considering dietary habits, sex, sun exposure, socioeconomic class and psychological factors.
Blood samples from 35 OLP patients and 35 healthy controls were collected for the analysis of serum VD level (SVDL) by ELISA. Vitamin D deficiency was considered when SVDL was ≤ 20 ng/ml. Additionally, a structured questionnaire was used to analyze other possible confounders.
SVDL were statistically significant greater in the control group than the OLP group (P ≤ 0.001). There was difference between the 3 types of OLP with statistical significance in which the least values for SVDL were in erosive type (P ≤ 0.001). Furthermore, no statistically significant difference was found in SVDL between dysplastic and non-dysplastic lesions. In terms of VD deficiency, a statistically significant distinction was noticed between the two research sets (P ≤ 0.001) and was more pronounced in erosive and atrophic types than reticular types. Depression as well as sun exposure significantly affected number of patients having VD deficiency (P = 0.001, 0.027). Results revealed a statistically significant direct relation between SVDL and the OLP (odds ratio = 1.38; 95%CI = 1.18-1.617).
VD deficiency plays a vital role in OLP and the development of more severe forms.
It corroborates that VD deficiency is a probable risk factor of OLP and the development of more severe forms considering many confounders.
考虑饮食习惯、性别、阳光照射、社会经济阶层和心理因素，研究维生素D（VD）缺乏作为口腔扁平苔藓（OLP）发生和严重程度风险因素的作用。
采集35例OLP患者和35例健康对照者的血样，采用酶联免疫吸附测定法（ELISA）分析血清VD水平（SVDL）。当SVDL≤20 ng/ml时，认为存在维生素D缺乏。此外，使用结构化问卷分析其他可能的混杂因素。
对照组的SVDL在统计学上显著高于OLP组（P≤0.001）。3种类型的OLP之间存在差异，具有统计学意义，其中SVDL最低值出现在糜烂型（P≤0.001）。此外，发育异常和非发育异常病变的SVDL之间未发现统计学上的显著差异。在VD缺乏方面，两组研究对象之间存在统计学上的显著差异（P≤0.001），在糜烂型和萎缩型中比网状型更明显。抑郁以及阳光照射显著影响VD缺乏患者的数量（P = 0.001，0.027）。结果显示SVDL与OLP之间存在统计学上的显著直接关系（优势比=1.38；95%置信区间=1.18 - 1.617）。
VD缺乏在OLP及其更严重形式的发生中起重要作用。
证实考虑到许多混杂因素，VD缺乏是OLP及其更严重形式的一个可能风险因素。
