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维生素D缺乏——儿童中的一个公共卫生问题。

Vitamin D Deficiency-A Public Health Issue in Children.

作者信息

Herdea Alexandru, Marie Harun, Ionescu Adelina, Sandu Diana-Mihaela, Pribeagu Sara-Teodora, Ulici Alexandru

机构信息

11th Department of Pediatric Orthopedics, "Carol Davila" University of Medicine and Pharmacy, Bd. Eroii Sanitari Nr. 8, 050474 Bucharest, Romania.

Pediatric Orthopedics Department, "Grigore Alexandrescu" Children's Emergency Hospital, 011743 Bucharest, Romania.

出版信息

Children (Basel). 2024 Aug 30;11(9):1061. doi: 10.3390/children11091061.

Abstract

BACKGROUND

25-hydroxyvitamin D [25(OH)D] deficiency is a global health concern, particularly in pediatric populations, with implications for musculoskeletal health and overall well-being. This study aimed to evaluate serum 25(OH)D levels in a pediatric population and assess the prevalence of deficiency and insufficiency.

METHODS

A retrospective analysis was conducted on data from 741 pediatric patients (2-17 years old) who visited an urban hospital for children for acute respiratory and gastrointestinal conditions in the span of 2 years. Serum 25(OH)D levels were measured using chemiluminescent microparticle immunoassay. Statistical analyses were performed to assess the prevalence of deficiency and insufficiency, seasonal variations, and correlations with age and daylight exposure.

RESULTS

Of the 739 pediatric patients analyzed, a substantial proportion exhibited insufficient (31.80%) or deficient (36.54%) serum 25(OH)D levels. While younger age groups generally had higher mean 25(OH)D levels, a negative correlation was observed between 25(OH)D levels and age. Sunlight exposure variations did not significantly impact serum 25(OH)D levels. Despite diverse daylight exposure patterns, there were no significant differences between longer and shorter daylight periods.

CONCLUSIONS

This study highlights the high prevalence of 25(OH)D deficiency and insufficiency in the pediatric population, emphasizing the need for public health monitoring and targeted supplementation strategies. Findings underscore the importance of regular consultations with healthcare providers to ensure optimal 25(OH)D levels in children, with potential implications for revising current sufficiency thresholds. Addressing 25(OH)D deficiency is crucial for promoting musculoskeletal health and overall well-being in children.

摘要

背景

25-羟维生素D [25(OH)D] 缺乏是一个全球性的健康问题,在儿科人群中尤为突出,对肌肉骨骼健康和整体健康状况都有影响。本研究旨在评估儿科人群的血清25(OH)D水平,并评估缺乏和不足的患病率。

方法

对741名2至17岁儿科患者的数据进行回顾性分析,这些患者在两年内因急性呼吸道和胃肠道疾病前往一家城市儿童医院就诊。采用化学发光微粒子免疫分析法测定血清25(OH)D水平。进行统计分析以评估缺乏和不足的患病率、季节变化以及与年龄和日照的相关性。

结果

在分析的739名儿科患者中,很大一部分患者的血清25(OH)D水平不足(31.80%)或缺乏(36.54%)。虽然较年轻的年龄组一般25(OH)D平均水平较高,但观察到25(OH)D水平与年龄之间呈负相关。日照变化对血清25(OH)D水平没有显著影响。尽管日照模式多样,但日照时间长短之间没有显著差异。

结论

本研究强调了儿科人群中25(OH)D缺乏和不足的高患病率,强调了公共卫生监测和有针对性的补充策略的必要性。研究结果强调了定期咨询医疗保健提供者以确保儿童25(OH)D水平达到最佳的重要性,这可能对修订当前的充足阈值有影响。解决25(OH)D缺乏问题对于促进儿童肌肉骨骼健康和整体健康状况至关重要。

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