Maufa Fuad, Al-Kawas Firas H
Division of Gastroenterology, Department of Medicine, MedStar Georgetown University Hospital, Georgetown University, 3800 Reservoir Road, NW, Washington, DC 20007, USA.
Int J Hepatol. 2012;2012:418369. doi: 10.1155/2012/418369. Epub 2012 Aug 9.
Acute variceal bleeding continues to be associated with significant mortality. Current standard of care combines hemodynamic stabilization, antibiotic prophylaxis, pharmacological agents, and endoscopic treatment. Rescue therapies using balloon tamponade or transjugular intrahepatic portosystemic shunt are implemented when first-line therapy fails. Rescue therapies have many limitations and are contraindicated in some cases. Placement of fully covered self-expandable metallic stent is a promising therapeutic technique that can be used to control bleeding in cases of refractory esophageal bleeding as an alternative to balloon tamponade. These stents can be left in place for as long as two weeks, allowing for improvement in liver function and institution of a more definitive treatment.
急性静脉曲张出血仍然与显著的死亡率相关。当前的治疗标准包括血流动力学稳定、抗生素预防、药物治疗和内镜治疗。当一线治疗失败时,采用球囊压迫或经颈静脉肝内门体分流术等挽救治疗。挽救治疗有许多局限性,在某些情况下是禁忌的。放置全覆膜自膨式金属支架是一种有前景的治疗技术,可用于控制难治性食管出血,作为球囊压迫的替代方法。这些支架可以留置长达两周,有助于肝功能改善并开展更确切的治疗。