Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester M13 9PT, U.K.
Essays Biochem. 2012;53:95-109. doi: 10.1042/bse0530095.
Cell polarization and cell division are two fundamental cellular processes. The mechanisms that establish and maintain cell polarity and the mechanisms by which cells progress through the cell cycle are now fairly well understood following decades of experimental work. There is also increasing evidence that the polarization state of a cell affects its proliferative properties. The challenge now is to understand how these two phenomena are mechanistically connected. The aim of the present chapter is to provide an overview of the evidence of cross-talk between apicobasal polarity and proliferation, and the current state of knowledge of the precise mechanism by which this cross-talk is achieved.
细胞极化和细胞分裂是两个基本的细胞过程。经过几十年的实验工作，细胞极性的建立和维持机制以及细胞如何通过细胞周期的机制已经相当清楚。越来越多的证据表明，细胞的极化状态会影响其增殖特性。现在的挑战是了解这两种现象在机制上是如何联系的。本章的目的是概述顶端-基底极性和增殖之间的串扰的证据，以及目前对这种串扰实现的确切机制的了解。
