Centre for DNA Fingerprinting and Diagnostics (CDFD), Nampally, Hyderabad 500 001, India.
J Biosci. 2014 Mar;39(1):145-55. doi: 10.1007/s12038-013-9410-z.
Apico-basal polarity is a cardinal molecular feature of adult eukaryotic epithelial cells and appears to be involved in several key cellular processes including polarized cell migration and maintenance of tissue architecture. Epithelial cell polarity is maintained by three well-conserved polarity complexes, namely, PAR, Crumbs and SCRIB. The location and interaction between the components of these complexes defines distinct structural domains of epithelial cells. Establishment and maintenance of apico-basal polarity is regulated through various conserved cell signalling pathways including TGF beta, Integrin and WNT signalling. Loss of cell polarity is a hallmark for carcinoma, and its underlying molecular mechanism is beginning to emerge from studies on model organisms and cancer cell lines. Moreover, deregulated expression of apico-basal polarity complex components has been reported in human tumours. In this review, we provide an overview of the apico-basal polarity complexes and their regulation, their role in cell migration, and finally their involvement in carcinogenesis.
顶端-基底极性是成年真核上皮细胞的主要分子特征，似乎参与了几个关键的细胞过程，包括极化细胞迁移和组织架构的维持。上皮细胞极性由三个高度保守的极性复合物维持，即 PAR、Crumb 和 SCRIB。这些复合物的成分的位置和相互作用决定了上皮细胞的不同结构域。顶端-基底极性的建立和维持通过包括 TGFβ、整合素和 WNT 信号在内的各种保守细胞信号通路进行调节。细胞极性的丧失是癌的标志，其潜在的分子机制开始从模式生物和癌细胞系的研究中显现出来。此外，在人类肿瘤中已经报道了顶端-基底极性复合物成分的表达失调。在这篇综述中，我们概述了顶端-基底极性复合物及其调节、它们在细胞迁移中的作用，以及它们在致癌作用中的参与。
