Nam Ha-Jong, Ryu Heongrae, Lee Da-Woon, Byeon Je Yeon, Kim Jun Hyuk, Lee Ji Hye, Lim Soomin, Choi Hwan Jun
Department of Plastic and Reconstructive Surgery, Soonchunhyang University Gumi Hospital, Gumi-si 39371, South Korea.
Department of Plastic and Reconstructive Surgery, College of Medicine, Soonchunhyang University, Cheonan-si 31151, South Korea.
World J Clin Cases. 2025 Mar 26;13(9):99463. doi: 10.12998/wjcc.v13.i9.99463.
The high prevalence of human papillomavirus (HPV) infection in oropharyngeal squamous cell carcinoma (SCC) is well established, and p16 expression is a strong predictor. HPV-related tumors exhibit unique mechanisms that target p16 and p53 proteins. However, research on HPV prevalence and the combined predictive value of p16 and p53 expression in head and neck cutaneous SCC (HNCSCC), particularly in Asian populations, remains limited. This retrospective study surveyed 62 patients with HNSCC (2011-2020), excluding those with facial warts or other skin cancer.
To explore the prevalence of HPV and the predictive value of p16 and p53 expression in HNCSCC in Asian populations.
All patients underwent wide excision and biopsy. Immunohistochemical staining for HPV, p16, and p53 yielded positive and negative results. The relevance of each marker was investigated by categorizing the tumor locations into high-risk and middle-risk zones based on recurrence frequency.
Of the 62 patients, 20 (32.26%) were male, with an average age of 82.27 years (range 26-103 years). High-risk included 19 cases (30.65%), with the eyelid and lip being the most common sites (five cases, 8.06%). Middle-risk included 43 cases (69.35%), with the cheek being the most common (29 cases, 46.77%). The p16 expression was detected in 24 patients (38.71%), p53 expression in 42 patients (72.58%), and HPV in five patients (8.06%). No significant association was found between p16 expression and the presence of HPV ( > 0.99), with a positive predictive value of 8.33%.
This study revealed that p16, a surrogate HPV marker in oropharyngeal SCC, is not reliable in HNCSCC, providing valuable insights for further research in Asian populations.
口咽鳞状细胞癌（SCC）中人类乳头瘤病毒（HPV）感染的高流行率已得到充分证实，并且p16表达是一个强有力的预测指标。HPV相关肿瘤表现出针对p16和p53蛋白的独特机制。然而，关于HPV流行率以及p16和p53表达在头颈部皮肤鳞状细胞癌（HNCSCC）中的联合预测价值的研究，尤其是在亚洲人群中，仍然有限。这项回顾性研究调查了62例HNSCC患者（2011 - 2020年），排除了患有面部疣或其他皮肤癌的患者。
探讨亚洲人群中HNCSCC患者HPV的流行率以及p16和p53表达的预测价值。
所有患者均接受了广泛切除和活检。HPV、p16和p53的免疫组织化学染色产生了阳性和阴性结果。通过根据复发频率将肿瘤位置分为高风险和中风险区域来研究每个标志物的相关性。
62例患者中，20例（32.26%）为男性，平均年龄82.27岁（范围26 - 103岁）。高风险组包括19例（30.65%），其中眼睑和唇部是最常见的部位（5例，8.06%）。中风险组包括43例（69.35%），其中脸颊是最常见的部位（29例，46.77%）。24例患者（38.71%）检测到p16表达，42例患者（72.58%）检测到p53表达，5例患者（8.06%）检测到HPV。未发现p16表达与HPV存在之间有显著关联（>0.99），阳性预测值为8.33%。
本研究表明，p16作为口咽SCC中HPV的替代标志物，在HNCSCC中不可靠，为亚洲人群的进一步研究提供了有价值的见解。
