Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Autoimmunity. 2012 Dec;45(8):593-6. doi: 10.3109/08916934.2012.719952. Epub 2012 Sep 21.
Evidences accumulated that the death of neutrophils are not the end of their missions. The neutrophil extracellular traps (NETs), web-like structure, formed after neutrophils dying contribute greatly to immune defense, in both innate and adaptive immunity. Interestingly, previous studies revealed that the generation and activation of NETs do not only rely on bacteria induction, but also in patients with sterile inflammatory diseases, implying an undeniable correlation between NETs and these diseases. This review summarized the latest findings that the crucial roles of NETs in sterile inflammatory diseases, as well as novel targeted therapy based on these new discoveries.
有证据表明，中性粒细胞的死亡并不是它们使命的终点。中性粒细胞胞外诱捕网（NETs）是一种网状结构，在中性粒细胞死亡后形成，对先天免疫和适应性免疫都有很大的贡献。有趣的是，先前的研究表明，NETs 的产生和激活不仅依赖于细菌的诱导，而且在无菌性炎症性疾病患者中也是如此，这表明 NETs 与这些疾病之间存在不可否认的关联。这篇综述总结了 NETs 在无菌性炎症性疾病中的关键作用以及基于这些新发现的新的靶向治疗的最新发现。
