Gritsuk A I, Glotov N A, Danilova I G, Segal' N K
Kosm Biol Aviakosm Med. 1990 Nov-Dec;24(6):37-9.
This paper presents data suggesting that tissue homogenates can be used to assess mitochondrial oxidation. The effect of hypokinesia of various duration on tissue respiration and oxidative phosphorylation of rat kidneys was investigated for the first time. It was found that 3-day hypokinesia led to a decrease of tissue respiration due to a lower contribution of endogenous fatty acids; 10-day hypokinesia caused activation of tissue respiration on endogenous and exogenous pyridine and flavoprotein-dependent substrates; 30-, 70- and 140-day hypokinesia brought about changes in energy formation at the expense of inhibition of respiratory activity of preparations and uncoupling of oxidative phosphorylation. Mechanisms of the above disturbances in energy metabolism reactions of kidneys are discussed.
本文提供的数据表明，组织匀浆可用于评估线粒体氧化。首次研究了不同时长的运动不足对大鼠肾脏组织呼吸和氧化磷酸化的影响。结果发现，3天的运动不足由于内源性脂肪酸的贡献降低导致组织呼吸下降；10天的运动不足导致内源性和外源性吡啶及黄素蛋白依赖性底物的组织呼吸激活；30天、70天和140天的运动不足导致能量形成发生变化，这是以抑制制剂的呼吸活性和氧化磷酸化解偶联为代价的。文中讨论了肾脏能量代谢反应中上述紊乱的机制。
