CIBERehd, Instituto Carlos III, Madrid, Spain.
Expert Rev Gastroenterol Hepatol. 2012 Aug;6(4):413-21. doi: 10.1586/egh.12.19.
The specific drugs available for chronic hepatitis B infection include standard and pegylated IFN-α, and nucleoside/nucleotide analogs that directly inhibit the reverse transcriptase. The main goal of current hepatitis B virus therapy is to achieve sustained suppression of viral replication to prevent the development of chronic liver disease, but favorable long-term tolerability and resistance profiles are also desirable. This article reviews the chemistry and the mechanisms of action of tenofovir disoproxil fumarate, but it also focuses on the related clinical trails designed to date, in which clinical efficacy has been analyzed attending to HBe antigen status. In addition, studies including patients that have been previously treated with lamivudine or adefovir are discussed.
用于慢性乙型肝炎感染的具体药物包括标准和聚乙二醇化干扰素-α，以及直接抑制逆转录酶的核苷/核苷酸类似物。目前乙型肝炎病毒治疗的主要目标是实现病毒复制的持续抑制，以防止慢性肝病的发展，但也需要良好的长期耐受性和耐药性特征。本文综述了富马酸替诺福韦二吡呋酯的化学和作用机制，但也重点介绍了迄今为止设计的相关临床试验，其中分析了根据 HBe 抗原状态的临床疗效。此外，还讨论了包括先前接受拉米夫定或阿德福韦治疗的患者的研究。
