哮喘炎症的消退。
Resolution of inflammation in asthma.
机构信息
Harvard Medical School, Department of Internal Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
出版信息
Clin Chest Med. 2012 Sep;33(3):559-70. doi: 10.1016/j.ccm.2012.06.006. Epub 2012 Jul 25.
Abstract
The resolution of inflammation in healthy airways is an active process, with specialized mediators and cellular mechanisms enlisted to restore tissue homeostasis. This article focuses on recent discoveries of natural mediators derived from essential fatty acids, including ω-3 fatty acids, with anti-inflammatory and pro-resolving. These pro-resolving mediators serve as agonists at specific receptors. Asthma is an incurable disease of chronic, nonresolving inflammation of the airways. While the biosynthesis of pro-resolving mediators occurs during asthma, defects in their production are associated with disease severity, suggesting that the pathobiology of asthma may result in part from impaired resolution of airway inflammation.
摘要
健康气道的炎症消退是一个主动的过程，其中专门的介质和细胞机制被募集来恢复组织的内稳态。本文主要关注从必需脂肪酸（包括 ω-3 脂肪酸）衍生的天然介质的最新发现，它们具有抗炎和促消退作用。这些促消退介质作为特定受体的激动剂发挥作用。哮喘是一种不可治愈的慢性气道炎症性疾病，具有非消退性特征。虽然在哮喘发生过程中会产生促消退介质，但它们的产生缺陷与疾病严重程度有关，这表明哮喘的病理生物学可能部分是由于气道炎症消退受损所致。
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