Kniznik D O, Alvarez C
Instituto de Investigaciones Médicas Alfredo Lanari, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
Medicina (B Aires). 1990;50(1):55-6.
A case of severe rhabdomyolysis with extensive myocardial involvement in a 32 year old alcoholic man is reported. He referred effort dyspnea for the last eight months which worsened thirteen days before his death. Admitted at the institute he was obnubilated and dyspneic. Massive pulmonary thromboembolism was suspected and heparin was given. He was then transferred to our intensive care unit in circulatory collapse. A chest Rx showed cardiomegaly. A Swan-Ganz catheter was introduced and abnormal parameters corrected. Evolution was complicated with acute cholecystitis, nosocomial bronchopneumonia and hypoxic brain damage. A net reduction of cardiac size as judged by a chest roentgenogram was noted in the final days. Necropsy showed skeletal and cardiac rhabdomyolysis, early alcoholic cirrhosis, diffuse peritonitis and bronchopneumonia. To our knowledge, this case is the first in the literature to provide anatomical evidence of cardiac rhabdomyolysis, a fact which was suspected on clinical grounds but had not been proven.
报告了一例32岁男性酒精性患者发生严重横纹肌溶解并累及广泛心肌的病例。他自述在过去八个月中出现劳力性呼吸困难,在去世前13天病情加重。入院时他神志不清且呼吸困难。怀疑有大面积肺血栓栓塞,给予肝素治疗。随后他因循环衰竭被转入我们的重症监护病房。胸部X线显示心脏扩大。插入了一根 Swan-Ganz 导管并纠正了异常参数。病情发展过程中并发了急性胆囊炎、医院获得性支气管肺炎和缺氧性脑损伤。在最后几天通过胸部X线片观察到心脏大小明显缩小。尸检显示骨骼肌和心肌横纹肌溶解、早期酒精性肝硬化、弥漫性腹膜炎和支气管肺炎。据我们所知,该病例是文献中首例提供心肌横纹肌溶解解剖学证据的病例,这一情况此前在临床上曾被怀疑但未得到证实。