[Cyclic nucleotide content in the adipocytes of rats with spontaneous genetic hypertension. Variations revealed by adrenalectomy].

The basal content of cAMP and cGMP in isolated adipose cells of rats with spontaneous genetic hypertension (SHR) was studied. No differences were found between SHR rats and animals with normal pressure in the content of cyclic nucleotides. Adrenalectomy changes essentially the content of cAMP and cGMP in the adipocytes, reducing the cAMP/cGMP ratio in the cells to about one half; the content of cAMP and cGMP is greater in the adipocytes of adrenalectomized SHR rats than in those of adrenalectomized animals with normal pressure.