[Characteristics of glucose absorption by the adipose tissue in renal and spontaneous hypertension in rats].

In vitro glucose-14C uptake by the epididymal adipose tissue was studied in young rats with spontaneous hypertension (SHR), in rats with two-kidney Goldblatt hypertension, and in control rats with normal pressure. Some of the animals were subjected to bilateral adrenalectomy one week before the study. Rats with either type of hypertension and intact adrenals did not differ from the controls in the intensity of glucose-14C uptake by the adipose tissue both with and without stimulation of its transmembranous tranport with insulin. Adrenalectomy revealed that the response of the adipose tissue to insulin in rats with hypertension differed from that in the controls. In the control animals adrenalectomy causes marked decrease in insulin "sensitivity" of the fat cells, whereas in adrenalectomized rats with hypertension the level of glucose-14C in stimulation of its transport with insulin does not change. The results of the study testify to qualitative changes in the membranes of the fat cells in rats with chronic arterial hypertension and may be proof of extensive alteration of the cell membranes in this disease.