Gerasimova E N, Perova N V, Zykova V P, Polesskiĭ V A, Bodrova E A
Kardiologiia. 1979 Dec;19(12):61-6.
Examination of 50 males aged from 40 to 59 years showed that an increase or decrease in the level of cholesterol of high-density lipoproteins (HDLP) occurs mostly at the expense of cholesterol of the HDLP2 subfraction. Changes in the concentration of sex hormones in the blood plasma are attended by a change in the number of HDLP2 particles, evidence of which was a change in the content of HDLP2 cholesterol and phospholipids with the level of HDLP3 cholesterol and phospholipids remaining unaltered. A higher content is attended by a rise in the level of HDLP2 cholesterol and HDLP2 phospholipids. A negative correlation between the level of estradiol and that of triglycerides in blood plasma (r=-0.61; p less than 0.01) and a positive correlation between the content of estradiol and the level of HDLP2 cholesterol and phospholipids (r=+0.34; p less than 0.05 and r=+0.37; p less than 0.05, respectively were revealed in males with estradiol concentration of 1--8 ng/dl. There was no correlation between the above-mentioned values when the concentration of estradiol in blood plasma was higher (8--16 ng/dl). In hypoalphalipoproteinemia and hypertriglyceridemia, the relation in very low density lipoproteins of apoprotein SH, which inhibits lipoprotein lipase, and apoprotein SP, which activates this enzyme, was higher than normal while the relation of these apoproteins in HDLP was lower.
对50名年龄在40至59岁之间的男性进行检查发现，高密度脂蛋白（HDLP）胆固醇水平的升高或降低主要是以HDLP2亚组分的胆固醇为代价的。血浆中性激素浓度的变化伴随着HDLP2颗粒数量的改变，其证据是HDLP2胆固醇和磷脂含量的变化，而HDLP3胆固醇和磷脂的水平保持不变。HDLP2胆固醇和HDLP2磷脂水平较高。在血浆雌二醇浓度为1--8 ng/dl的男性中，发现血浆雌二醇水平与甘油三酯水平呈负相关（r=-0.61；p<0.01），雌二醇含量与HDLP2胆固醇和磷脂水平呈正相关（r=+0.34；p<0.05和r=+0.37；p<0.05）。当血浆雌二醇浓度较高（8--16 ng/dl）时，上述值之间没有相关性。在低α脂蛋白血症和高甘油三酯血症中，抑制脂蛋白脂肪酶的载脂蛋白SH与激活该酶的载脂蛋白SP在极低密度脂蛋白中的关系高于正常水平，而这些载脂蛋白在HDLP中的关系则较低。
