Aksoy Fadlullah, Yıldırım Yavuz Selim, Veyseller Bayram, Demirhan Hasan, Ozturan Orhan
Department of Otorhinolaryngology and Head and Neck Surgery, Haseki Research and Training Hospital, Istanbul, Turkey.
Ear Nose Throat J. 2012 Aug;91(8):E32-5.
Patients with asthma, allergic rhinitis, or atopic dermatitis experience increased oxidative stress. We conducted a prospective study to examine the levels of advanced oxidation protein products (AOPPs) as an indicator of oxidative stress in 97 patients with allergic rhinitis who were followed in our clinic during a 3.5-month period. Of these 97 patients, 51 were treated with subcutaneous immunotherapy (SCIT), and 46 did not receive any treatment until the study was concluded. In each patient, allergic rhinitis and allergic sensitization were documented by the history, the findings on clinical examination, and the results of blood and skin-prick tests. Blood samples from each patient were analyzed to determine AOPP levels. We found that the mean serum AOPP level was significantly higher in the SCIT group than in the non-SCIT group (258.55 vs. 163.83 µmol/L; p = 0.0015). We conclude that as a known indicator of protein oxidation, the serum AOPP level is a marker of increased oxidative stress in response to allergen exposure in allergic rhinitis.
哮喘、过敏性鼻炎或特应性皮炎患者会经历氧化应激增加的情况。我们进行了一项前瞻性研究，以检查晚期氧化蛋白产物（AOPP）水平，作为氧化应激的指标，研究对象为97例在我们诊所随访3.5个月的过敏性鼻炎患者。在这97例患者中，51例接受了皮下免疫疗法（SCIT），46例在研究结束前未接受任何治疗。在每位患者中，通过病史、临床检查结果以及血液和皮肤点刺试验结果记录过敏性鼻炎和过敏致敏情况。对每位患者的血样进行分析以确定AOPP水平。我们发现，SCIT组的平均血清AOPP水平显著高于非SCIT组（258.55对163.83 µmol/L；p = 0.0015）。我们得出结论，作为蛋白质氧化的已知指标，血清AOPP水平是过敏性鼻炎患者接触过敏原后氧化应激增加的标志物。
