Department of Chemistry, Tokyo Institute of Technology, O-okayama, Meguro-ku, Tokyo 152-8551, Japan.
Org Biomol Chem. 2012 Oct 14;10(38):7685-8. doi: 10.1039/c2ob26337h.
A catechin hetero-trimer isolated from Ziziphus jujuba has been synthesized. Among three constituent monomers, (-)-epiafzelechin and (-)-epigallocatechin were prepared by de novo synthesis. Trimer formation relied on the unified approach to oligomers based on the bromo-capping and the orthogonal activation, reaching the reported structure of the natural product.
从酸枣中分离得到的表儿茶素杂三聚体已被合成。在三个组成单体中，(-)-表儿茶素和(-)-表没食子儿茶素通过从头合成制备。三聚体的形成依赖于基于溴封端和正交激活的寡聚物统一方法，得到了天然产物的报道结构。
