Guo Y-L, You K, Qiao J, Zhao Y-m, Geng L
Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.
Int J STD AIDS. 2012 Aug;23(8):581-4. doi: 10.1258/ijsa.2012.011342.
We investigated the effects of bacterial vaginosis (BV) on the outcomes of high-risk human papillomavirus infection (HR-HPV). BV was diagnosed on Papanicolaou-stained cytology slides of 707 HPV-positive patients. HR-HPV DNA expression was analysed using the Hybrid Capture II (HC-II) assay. Of the 707 HR-HPV-positive female patients, 298 (42.1%) exhibited clearance of HR-HPV. The remaining 409 patients had persistent HR-HPV infection. The persistent HR-HPV group and the clearing group had similar rates of BV at the beginning of the study. At the end of the study, the persistent HR-HPV group had a BV prevalence of 11.2% while the clearing group had a significant lower BV prevalence of 5.0%. A decreased clearance of HPV was found in women with current BV, compared with women without BV. Furthermore, the natural history of HPV was not affected by the HPV viral load or the BV prevalence at the beginning of the study (P > 0.05). Bacterial vaginosis appears conducive to the persistence of HPV infection.
我们研究了细菌性阴道病（BV）对高危型人乳头瘤病毒感染（HR-HPV）结局的影响。通过对707例HPV阳性患者的巴氏染色细胞学涂片诊断BV。采用杂交捕获二代（HC-II）检测法分析HR-HPV DNA表达。在707例HR-HPV阳性女性患者中，298例（42.1%）出现HR-HPV清除。其余409例患者存在持续性HR-HPV感染。在研究开始时，持续性HR-HPV感染组和清除组的BV发生率相似。研究结束时，持续性HR-HPV感染组的BV患病率为11.2%，而清除组的BV患病率显著较低，为5.0%。与无BV的女性相比，现患BV的女性HPV清除率降低。此外，HPV的自然病程不受研究开始时HPV病毒载量或BV患病率的影响（P>0.05）。细菌性阴道病似乎有利于HPV感染的持续存在。
