Case Western Reserve University School of Medicine, Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, OH.
Am J Clin Pathol. 2019 Jul 5;152(2):185-189. doi: 10.1093/ajcp/aqz021.
Human papillomavirus (HPV) is known to be associated with squamous intraepithelial lesions (SILs). However, there is limited and conflicting literature on the relationship between bacterial vaginosis (BV) and SIL. The aim of this study is to determine the prevalence of BV and evaluate the association between BV and SIL.
A retrospective study was performed on 10,546 cases between 2012 and 2017. HPV results were available in 7,081 cases.
BV was present in 17.6% of cases. There was significant association between BV, positive HPV infection, and high-grade SIL. BV patients with negative HPV infection showed more squamous abnormalities than BV-negative HPV-negative patients.
We found there is a significant association between BV and SIL. BV is more common among patients with HPV infection and is independently associated with squamous abnormalities in cervical smears and surgical follow-up.
人乳头瘤病毒（HPV）已知与鳞状上皮内病变（SIL）有关。然而，细菌性阴道病（BV）与 SIL 之间的关系的相关文献有限且存在争议。本研究旨在确定 BV 的患病率，并评估 BV 与 SIL 之间的关系。
对 2012 年至 2017 年间的 10546 例病例进行回顾性研究。7081 例有 HPV 结果。
BV 在 17.6%的病例中存在。BV 与 HPV 阳性感染和高级别 SIL 之间存在显著关联。HPV 阴性的 BV 患者的鳞状异常比 HPV 阴性的 BV 阴性患者更多。
我们发现 BV 与 SIL 之间存在显著关联。BV 在 HPV 感染患者中更为常见，并且与宫颈涂片和手术随访中的鳞状异常独立相关。
