Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
J Epidemiol Community Health. 2013 Feb;67(2):194-7. doi: 10.1136/jech-2012-201312. Epub 2012 Aug 27.
To analyse the relationship between objectively measured daily walking duration and cardiovascular biomarkers of inflammation, cardiac dysfunction and renal impairment.
Between March 2009 and April 2010, physical activity was assessed in 1253 community-dwelling individuals living in Germany aged ≥65 years (57% men) over 1 week using a thigh-worn accelerometer. C reactive protein (CRP), white blood cells (WBC), N-terminal pro-brain natriuretic peptide, high-sensitive troponin T (hsTnT), creatinine (Cr) and cystatin C (CysC) were also measured. Least-square means of daily walking duration were calculated for quartiles of each biomarker adjusted for sex, age, pre-existing cardiovascular disease and smoking status.
After adjustment for covariates, statistically significant linear associations with walking duration were observed for WBC, hsTnT, Cr and CysC. CRP quartiles 1 and 2 showed no significant difference followed by a significant inverse dose-response relationship. A similar pattern, but less pronounced, was seen for N-terminal pro-brain natriuretic peptide. Mean differences between the first two quartiles of CRP and its fourth quartile were 17 min. Between categories 1 (more beneficial) and 4 of WBC, hsTnT, Cr and CysC the differences were 15, 12, 23 and 20 min, respectively.
Increased walking duration is associated with a more favourable profile of cardiovascular biomarkers in elderly subjects.
分析客观测量的日常步行时长与心血管炎症生物标志物、心功能障碍和肾功能损害之间的关系。
2009 年 3 月至 2010 年 4 月，在德国居住的 1253 名年龄≥65 岁的社区居民（57%为男性）中，使用大腿佩戴的加速度计在一周内评估身体活动情况。还测量了 C 反应蛋白（CRP）、白细胞（WBC）、N 末端脑利钠肽前体、高敏肌钙蛋白 T（hsTnT）、肌酐（Cr）和胱抑素 C（CysC）。根据性别、年龄、既往心血管疾病和吸烟状况，对每个生物标志物的四分位数据进行了最小二乘法（least-square means），计算了日常步行时长的中位数。
在调整协变量后，与步行时长呈统计学显著线性关联的标志物包括 WBC、hsTnT、Cr 和 CysC。CRP 四分位 1 和 2 之间无显著差异，随后呈现显著的反向剂量反应关系。N 末端脑利钠肽前体也呈现出类似的模式，但程度较轻。CRP 前两个四分位与第四四分位之间的平均差异为 17 分钟。CRP 和 WBC、hsTnT、Cr 和 CysC 的第 1 类（更有益）和第 4 类之间的差异分别为 15、12、23 和 20 分钟。
在老年人群中，增加步行时长与心血管生物标志物的更有利谱相关。
