Ackerman N B, Makohon S
Microcirc Endothelium Lymphatics. 1984 Oct;1(5):547-68.
The effects of epinephrine on the vascularity of tumors within the liver of rats were studied by simultaneous injection of Microfil into the arterial and portal systems. A marked increase in perfusion of capillary-sized vessels within the central portions of the tumor was observed in both induced hepatomas and implanted Walker carcinosarcoma tumors. In studies with implanted tumors, the effect of epinephrine on enhancing vascularity internally was eliminated by the alpha adrenergic block agent phenoxybenzamine, but was not affected by the beta adrenergic blocking agent propranolol.
通过同时将微丝（Microfil）注入动脉和门静脉系统，研究了肾上腺素对大鼠肝脏内肿瘤血管分布的影响。在诱导性肝癌和植入性沃克癌肉瘤肿瘤中，均观察到肿瘤中央部分毛细血管大小血管的灌注显著增加。在植入性肿瘤的研究中，肾上腺素增强内部血管分布的作用可被α肾上腺素能阻滞剂酚苄明消除，但不受β肾上腺素能阻滞剂普萘洛尔的影响。
