二硫代氨基甲酸盐配合物作为医学成像的放射性药物。
Dithiocarbamate complexes as radiopharmaceuticals for medical imaging.
机构信息
King's College London, Division of Imaging Sciences and Biomedical Engineering, 4th Floor Lambeth Wing, St Thomas Hospital, London SE1 7EH, UK.
出版信息
Mini Rev Med Chem. 2012 Oct;12(12):1174-83. doi: 10.2174/138955712802762112.
Abstract
Over the past 30 years dithiocarbamate ligands have found application in radiopharmaceutical metal-ligand complexes to image a range of disease states. The vast majority of research and applications, and the widest range of complex structures, have involved radionuclides of technetium and rhenium. Considering the extent of coordination chemistry of dithiocarbamate ligands described elsewhere in this issue, the extent of radiopharmaceutical application with metallic radionuclides is surprisingly narrow. Here we summarise the types of radiopharmaceutical complexes studied and the uses, and potential uses, to which they have been put in nuclear medicine.
摘要
在过去的 30 年中，二硫代氨基甲酸盐配体已应用于放射性药物金属配体络合物，以成像多种疾病状态。绝大多数的研究和应用，以及最广泛的配合物结构，都涉及到锝和铼的放射性核素。考虑到本期中其他地方描述的二硫代氨基甲酸盐配体的配位化学程度，用金属放射性核素进行放射性药物应用的程度非常有限。在这里，我们总结了研究过的放射性药物配合物的类型以及它们在核医学中的用途和潜在用途。
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