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正电子发射断层显像放射性药物中铜放射性核素的螯合剂。

Chelators for copper radionuclides in positron emission tomography radiopharmaceuticals.

作者信息

Cai Zhengxin, Anderson Carolyn J

机构信息

Department of Radiology, University of Pittsburgh, Pittsburgh, PA, 15219, USA.

出版信息

J Labelled Comp Radiopharm. 2014 Apr;57(4):224-30. doi: 10.1002/jlcr.3165. Epub 2013 Dec 18.

DOI:10.1002/jlcr.3165
PMID:24347474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4277819/
Abstract

The development of chelating agents for copper radionuclides in positron emission tomography radiopharmaceuticals has been a highly active and important area of study in recent years. The rapid evolution of chelators has resulted in highly specific copper chelators that can be readily conjugated to biomolecules and efficiently radiolabeled to form stable complexes in vivo. Chelators are not only designed for conjugation to monovalent biomolecules but also for incorporation into multivalent targeting ligands such as theranostic nanoparticles. These advancements have strengthened the role of copper radionuclides in the fields of nuclear medicine and molecular imaging. This review emphasizes developments of new copper chelators that have most greatly advanced the field of copper-based radiopharmaceuticals over the past 5 years.

摘要

近年来，用于正电子发射断层显像放射性药物中铜放射性核素的螯合剂开发一直是一个非常活跃且重要的研究领域。螯合剂的快速发展已产生了高度特异性的铜螯合剂，这些螯合剂可以很容易地与生物分子共轭，并在体内有效地进行放射性标记以形成稳定的复合物。螯合剂不仅设计用于与单价生物分子共轭，还用于掺入多价靶向配体，如诊疗纳米颗粒。这些进展加强了铜放射性核素在核医学和分子成像领域的作用。本综述着重介绍了过去5年中极大推动了铜基放射性药物领域发展的新型铜螯合剂的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e60d/4277819/f8ae822e2292/nihms648665f6.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e60d/4277819/f8ae822e2292/nihms648665f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e60d/4277819/90e70042f35c/nihms648665f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e60d/4277819/5a81b8dcc1a4/nihms648665f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e60d/4277819/db8632dde69e/nihms648665f3.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e60d/4277819/f8ae822e2292/nihms648665f6.jpg

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