Chizhov A Ia, Osipenko A V, Egorova E B
Patol Fiziol Eksp Ter. 1990 Sep-Oct(5):37-9.
Energy metabolism of maternal and fetal tissues in adaptation to intermittent normobaric hypoxia was studied in experiments on 72 female Wistar rats. During pregnancy the intensity of tissue respiration in myometry was more than twice that in a nonpregnant uterus. The rate of tissue respiration in vital organs (brain) remained at a high level irrespective of exposure to the effect of a gas hypoxic mixture containing 10% oxygen, i.e. the organism of the mother and fetus provides the developing brain with an optimum amount of oxygen even in its possible deficiency. Thus, adaptation of the maternal and fetal organism to GHM-10 is attended by some shifts in energy metabolism which maintain the aerobic oxidation metabolism in the studied tissues for a long duration through more effective consumption of oxygen in its lack.
在对72只雌性Wistar大鼠进行的实验中，研究了母体和胎儿组织在适应间歇性常压缺氧时的能量代谢。在怀孕期间，子宫肌层组织呼吸的强度是非妊娠子宫的两倍多。重要器官（大脑）的组织呼吸速率保持在较高水平，而不受含10%氧气的气体低氧混合物影响，即即使在可能缺氧的情况下，母体和胎儿的机体也能为发育中的大脑提供最佳量的氧气。因此，母体和胎儿机体对含10%氧气的气体低氧混合物的适应伴随着能量代谢的一些变化，这些变化通过在缺氧时更有效地消耗氧气，长时间维持所研究组织中的有氧氧化代谢。
