Yamada Yuichiro
Department of Endocrinology, Diabetes and Geriatric Medicine, Akita University Graduate School of Medicine, Japan.
Clin Calcium. 2012 Sep;22(9):1353-8.
GLP-1 and GIP play an important role as incretin to stimulate insulin secretion from pancreatic β-cells and to maintain the homeostasis of glucose metabolism. As GLP-1 receptors are expressed in thyroid C cells and GIP receptors are expressed in osteoblasts, incretin contributes to bone metabolism. GIP maintains the homeostasis of bone metabolism through transiently activating osteoblasts.
胰高血糖素样肽-1（GLP-1）和葡萄糖依赖性促胰岛素多肽（GIP）作为肠促胰岛素，在刺激胰腺β细胞分泌胰岛素以及维持葡萄糖代谢稳态方面发挥着重要作用。由于GLP-1受体在甲状腺C细胞中表达，GIP受体在成骨细胞中表达，肠促胰岛素有助于骨代谢。GIP通过短暂激活成骨细胞来维持骨代谢稳态。
