Kanazawa Ippei
Internal Medicine 1, Shimane University Faculty of Medicine, Japan.
Clin Calcium. 2014 Nov;24(11):1671-7.
There are two kinds of incretin, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) . GIP directly affects osteoblasts and osteoclasts, resulting in increasing bone mass by enhancing bone formation and suppressing bone resorption. On the other hand, GLP-1 does not affect bone directly. GLP-1 is reported to stimulate calcitonin secretion in thyroid gland and then indirectly increase bone mass. Dipeptidyl peptidase-4 inhibitors, which activate the function of incretin, may decrease the risk of osteoporotic fractures. In addition, it has been shown that osteoblast-derived osteocalcin stimulates GLP-1 secretion. Therefore, there may be an interaction between bone and digestive tract.
存在两种肠促胰岛素，即葡萄糖依赖性促胰岛素多肽（GIP）和胰高血糖素样肽-1（GLP-1）。GIP直接影响成骨细胞和破骨细胞，通过增强骨形成和抑制骨吸收来增加骨量。另一方面，GLP-1不直接影响骨骼。据报道，GLP-1可刺激甲状腺中降钙素的分泌，进而间接增加骨量。激活肠促胰岛素功能的二肽基肽酶-4抑制剂可能会降低骨质疏松性骨折的风险。此外，研究表明成骨细胞衍生的骨钙素可刺激GLP-1的分泌。因此，骨骼与消化道之间可能存在相互作用。
