Yoshizawa Tatsuya
Department of Medical Biochemistry, Faculty of Life Science, Kumamoto University, Japan.
Clin Calcium. 2012 Sep;22(9):1367-73.
Recently, we reported that insulin signaling in osteoblasts was a positive regulator of bone acquisition, but also of bone resorption. Interestingly, insulin signaling in osteoblasts activated osteocalcin embedded in bone ECM by stimulating resorption activity in osteoclast. It has been demonstrated that activated osteocalcin acts as hormone and regulates glucose metabolism through increasing insulin secretion from pancreas. The interaction of bone and glucose metabolism established by these studies will be important to a study of the two scientific fields in the future, particularly a clinical field.
最近，我们报道成骨细胞中的胰岛素信号不仅是骨形成的正调节因子，也是骨吸收的正调节因子。有趣的是，成骨细胞中的胰岛素信号通过刺激破骨细胞的吸收活性来激活嵌入骨细胞外基质中的骨钙素。已经证明，活化的骨钙素作为一种激素，通过增加胰腺胰岛素分泌来调节葡萄糖代谢。这些研究建立的骨与葡萄糖代谢之间的相互作用，对未来这两个科学领域的研究，尤其是临床领域的研究将具有重要意义。
