Department of Neurology and Neuroscience, Weill Cornell Medical College, 525 East 68th Street, New York, NY, USA.
Neurocrit Care. 2012 Dec;17(3):343-7. doi: 10.1007/s12028-012-9772-3.
Although there are extensive data on long-term disability after subarachnoid hemorrhage (SAH), there are few data on the trajectory of functional recovery after hospital discharge.
From October 2009 to April 2010, we prospectively followed consecutive patients with non-traumatic SAH discharged from a university hospital. Modified Rankin Scale (mRS) scores were calculated at discharge from chart review and at 6 months by standardized telephone interview. Good functional status was defined as a mRS score of 0-2, and poor status as an mRS score of 3-6. Descriptive statistics were used to assess the trajectory of functional recovery and determine the proportion of patients whose functional status improved from poor to good.
Among 52 patients with non-traumatic SAH (79 % aneurysmal) who were discharged alive, most (71 %) were discharged home. Median (IQR) mRS score was 3 (2-4) at discharge and 2 (1-2) at 6 months. Some functional recovery (any improvement in mRS score) was seen in most patients (83 %; 95 % CI, 72-93 %). Of the 28 patients with poor functional status at discharge, 16 (57 %) improved to good functional status at 6 months. All patients with Hunt-Hess grade 4 or 5 hemorrhages (n = 14) had poor functional status at discharge, but half (95 % CI, 20-80 %) recovered to a good functional status at 6 months.
Although our sample size is small, our findings suggest that a substantial proportion of patients with SAH who are disabled at discharge go on to regain functional independence within 6 months.
尽管有大量关于蛛网膜下腔出血(SAH)后长期残疾的数据,但关于出院后功能恢复轨迹的数据很少。
从 2009 年 10 月到 2010 年 4 月,我们前瞻性地随访了从一所大学医院出院的连续非创伤性 SAH 患者。通过病历回顾和标准化电话访谈,在出院时和 6 个月时计算改良 Rankin 量表(mRS)评分。良好的功能状态定义为 mRS 评分为 0-2,不良状态定义为 mRS 评分为 3-6。使用描述性统计来评估功能恢复的轨迹,并确定功能状态从不良改善为良好的患者比例。
在 52 例非创伤性 SAH(79%为动脉瘤性)出院存活的患者中,大多数(71%)出院回家。出院时中位数(IQR)mRS 评分为 3(2-4),6 个月时为 2(1-2)。大多数患者(83%;95%CI,72-93%)出现了一些功能恢复(mRS 评分任何改善)。在出院时功能状态较差的 28 例患者中,有 16 例(57%)在 6 个月时改善为功能状态良好。所有(n=14)Hunt-Hess 分级 4 或 5 级出血的患者出院时功能状态较差,但有一半(95%CI,20-80%)在 6 个月时恢复为良好功能状态。
尽管我们的样本量较小,但我们的发现表明,出院时残疾的 SAH 患者中有相当大的比例在 6 个月内恢复了功能独立性。