发现源自基因内重组的严重发热伴血小板减少综合征布尼亚病毒株。
Discovery of severe fever with thrombocytopenia syndrome bunyavirus strains originating from intragenic recombination.
机构信息
College of Life Science, Shandong Normal University, Jinan, China.
出版信息
J Virol. 2012 Nov;86(22):12426-30. doi: 10.1128/JVI.01317-12. Epub 2012 Aug 29.
Abstract
This study analyzes available severe fever with thrombocytopenia syndrome virus (SFTSV) genomes and reports that a sublineage of lineage I bears a unique M segment recombined from two of three prevailing SFTSV lineages. Through recombination, the sublineage has acquired nearly complete G1 associated with protective epitopes from lineage III, suggesting that this recombination has the capacity to induce antigenic shift of the virus. Therefore, this study provides some valuable implications for the vaccine design of SFTSV.
摘要
本研究分析了现有的发热伴血小板减少综合征病毒 (SFTSV) 基因组，并报告了 I 谱系的一个亚谱系具有独特的 M 片段，该片段来自三种流行的 SFTSV 谱系中的两个。通过重组，该亚谱系获得了与来自谱系 III 的保护性表位相关的几乎完整的 G1，表明这种重组有能力诱导病毒的抗原转变。因此，本研究为 SFTSV 的疫苗设计提供了一些有价值的启示。
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