乳酸脱氢酶升高病毒感染小鼠中的抗体非依赖性血小板减少症。
Antibody-independent thrombocytopenia in lactate dehydrogenase-elevating virus-infected mice.
机构信息
Unit of Experimental Medicine, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.
出版信息
J Virol. 2012 Nov;86(22):12414-6. doi: 10.1128/JVI.00745-12. Epub 2012 Aug 29.
Abstract
Previously we demonstrated that antibody-mediated thrombocytopenia is strongly enhanced by lactate dehydrogenase-elevating virus (LDV) infection. Here we report that mice infected with LDV develop a moderate thrombocytopenia, even in the absence of immunoglobulins or Fc receptors. A similar decrease of platelet counts was observed after mouse hepatitis virus infection. LDV-induced type I interferon-independent thrombocytopenia was partly suppressed by treatment with clodronate-containing liposomes. Therefore, we conclude that the thrombocytopenia results from increased phagocytosis of nonopsonized platelets by macrophages.
摘要
此前我们证明了乳酸脱氢酶升高病毒（LDV）感染可显著增强抗体介导的血小板减少症。在此我们报告称，感染 LDV 的小鼠即使没有免疫球蛋白或 Fc 受体也会发生中度血小板减少症。在感染鼠肝炎病毒后也观察到血小板计数类似的减少。用含有氯膦酸盐的脂质体进行治疗可部分抑制 LDV 诱导的 I 型干扰素非依赖性血小板减少症。因此，我们得出结论，血小板减少症是由巨噬细胞对非调理血小板的吞噬作用增加所致。
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