小鼠病毒感染后白细胞介素-12基因的表达
Interleukin-12 gene expression after viral infection in the mouse.
作者信息
Coutelier J P, Van Broeck J, Wolf S F
机构信息
Unit of Experimental Medicine, Catholic University of Louvain, Brussels, Belgium.
出版信息
J Virol. 1995 Mar;69(3):1955-8. doi: 10.1128/JVI.69.3.1955-1958.1995.
Abstract
Interleukin-12 is a lymphokine that triggers gamma interferon secretion by various cells and differentiation of T-helper lymphocytes towards the Th1 subtype. Since viruses are potent inducers of gamma interferon production and elicit immune responses most probably mediated by Th1 cells, like B-cell immunoglobulin G2a secretion, we analyzed interleukin-12 message expression after infection of mice with lactate dehydrogenase-elevating virus, mouse hepatitis virus, and mouse adenovirus. Our results indicated that the message for the p40 component of interleukin-12 was transiently increased shortly after infection. Interleukin-12 was expressed mainly by macrophages. Therefore, production of interleukin-12 might constitute the initial event that would determine the subsequent characteristics of the immune response elicited by viral infections.
摘要
白细胞介素-12是一种淋巴因子，可触发各种细胞分泌γ干扰素，并促使辅助性T淋巴细胞分化为Th1亚型。由于病毒是γ干扰素产生的强效诱导剂，且引发的免疫反应很可能由Th1细胞介导，如B细胞免疫球蛋白G2a的分泌，因此我们分析了用乳酸脱氢酶升高病毒、小鼠肝炎病毒和小鼠腺病毒感染小鼠后白细胞介素-12信使表达情况。我们的结果表明，感染后不久，白细胞介素-12的p40成分的信使短暂增加。白细胞介素-12主要由巨噬细胞表达。因此，白细胞介素-12的产生可能构成决定病毒感染引发的免疫反应后续特征的初始事件。
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