Jones A W, Hahn R G, Stalberg H P
Department of Alcohol Toxicology, National Laboratory of Forensic Chemistry, University Hospital, Linköping, Sweden.
Scand J Clin Lab Invest. 1990 Nov;50(7):775-80. doi: 10.1080/00365519009091072.
Hospital patients (n = 17) received 0.216 mmol/min kg body weight of ethanol as an intravenous infusion over 60 min. At fixed time intervals during and after administration, two consecutive samples of whole blood (5 ml each) were taken from a cubital vein. The plasma fraction was obtained by centrifugation of one of the tubes. The concentrations of ethanol in whole blood and plasma were determined by headspace gas chromatography and the water contents of the specimens by desiccation. The mean plasma:whole blood ratio of ethanol was 1.10:1, range 1.03:1 to 1.24:1 (n = 159). The components of variance (SD) within subjects and between subjects were 0.0293 (CV 2.7%) and 0.0165 (CV 1.5%) respectively. The 95% confidence interval ranged from 1.03:1 to 1.16:1 for a single new determination in a subject from the same population. The average water content in plasma and whole blood were 91.8% w/w (SD 0.49) and 80.1% w/w (SD 1.03) respectively. Neither the mean plasma:blood ratio of ethanol nor the water content of the specimens depended on sampling time after ethanol administration.
17名住院患者以0.216毫摩尔/分钟·千克体重的乙醇进行静脉输注，持续60分钟。在给药期间及给药后，按固定时间间隔从肘静脉采集两份连续的全血样本（每份5毫升）。其中一份样本经离心获得血浆部分。全血和血浆中的乙醇浓度通过顶空气相色谱法测定，样本的含水量通过干燥法测定。乙醇的平均血浆与全血比值为1.10:1，范围为1.03:1至1.24:1（n = 159）。受试者内和受试者间的方差成分（标准差）分别为0.0293（变异系数2.7%）和0.0165（变异系数1.5%）。对于来自同一人群的受试者进行的单次新测定，95%置信区间为1.03:1至1.16:1。血浆和全血中的平均含水量分别为91.8%（重量/重量，标准差0.49）和80.1%（重量/重量，标准差1.03）。乙醇的平均血浆与全血比值以及样本的含水量均不取决于乙醇给药后的采样时间。
