Jones A W
Clin Chem. 1979 Aug;25(8):1394-8.
The inter- and intra-individual components of variation in the saliva/blood alcohol ratio have been calculated from experiments with 48 male subjects after they drank 0.72 g of ethanol per kilogram of body weight as neat whisky after a short fast. Saliva and blood ethanol profiles were monitored at 30--60 min intervals for up to 7 h after intake. The analytical component of variation inherent in an estimate of the saliva/blood alcohol ratio, expressed as coefficient of variation, was 1.75%. I calculated saliva/blood ethanol ratios for each subject at each sampling time by taking the antilogarithm of the difference (log saliva alcohol--log blood alcohol). The mean ratio between 60 and 360 min after drinking was 1.077 (n = 336) with 95% confidence limits of 1.065 and 1.088. Moreover, the individual ratios showed no systematic variation throughout the absorption, distribution, and elimination phases of ethanol metabolism. Using a two-way analysis of variance and allowing for analytical sources of variation, I determined that the inter- and intra-subject variance components were 53 and 47% of the total biological variation. The saliva/blood alcohol ratio during ethanol metabolism, determined once in a single individual, had a biologically derived coefficient of variation of 10%.
在48名男性受试者短期禁食后饮用每千克体重0.72克纯威士忌形式的乙醇后，已根据实验计算出唾液/血液酒精比率个体间和个体内变异成分。摄入后，每隔30 - 60分钟监测唾液和血液乙醇水平，长达7小时。唾液/血液酒精比率估计值中固有的分析变异成分，以变异系数表示为1.75%。我通过取差值（log唾液酒精 - log血液酒精）的反对数，计算每个受试者在每个采样时间的唾液/血液乙醇比率。饮酒后6０至360分钟之间的平均比率为1.077（n = 336），95%置信区间为1.065至1.088。此外，个体比率在乙醇代谢的整个吸收、分布和消除阶段均未显示出系统变化。通过双向方差分析并考虑分析变异来源，我确定受试者间和受试者内方差成分分别占总生物学变异的53%和47%。在乙醇代谢期间，对单个个体进行一次测定的唾液/血液酒精比率，其生物学衍生变异系数为10%。
