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Oral gene application using chitosan-DNA nanoparticles induces transferable tolerance.使用壳聚糖-DNA纳米颗粒的口服基因应用可诱导可转移的耐受性。
Clin Vaccine Immunol. 2012 Nov;19(11):1758-64. doi: 10.1128/CVI.00186-12. Epub 2012 Aug 29.
2
Induction of ovalbumin-specific tolerance by oral administration of Lactococcus lactis secreting ovalbumin.通过口服分泌卵清蛋白的乳酸乳球菌诱导卵清蛋白特异性耐受。
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3
Oral tolerance induction with antigen conjugated to cholera toxin B subunit generates both Foxp3+CD25+ and Foxp3-CD25- CD4+ regulatory T cells.用与霍乱毒素B亚基偶联的抗原诱导口服耐受可产生Foxp3 + CD25 +和Foxp3 - CD25 - CD4 +调节性T细胞。
J Immunol. 2006 Dec 1;177(11):7634-44. doi: 10.4049/jimmunol.177.11.7634.
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Targeting the allergen to oral dendritic cells with mucoadhesive chitosan particles enhances tolerance induction.用粘膜粘附性壳聚糖颗粒将变应原靶向递送至口腔树突状细胞可增强耐受性诱导。
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CD4+CD25-mTGFbeta+ T cells induced by nasal application of ovalbumin transfer tolerance in a therapeutic model of asthma.鼻内应用卵清蛋白诱导 CD4+CD25-mTGFβ+T 细胞转移耐受在哮喘治疗模型中的作用。
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Induction of antigen-specific immune tolerance using biodegradable nanoparticles containing antigen and dexamethasone.使用载抗原和地塞米松的可生物降解纳米颗粒诱导抗原特异性免疫耐受。
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Dual role of CpG as immune modulator and physical crosslinker in ovalbumin loaded N-trimethyl chitosan (TMC) nanoparticles for nasal vaccination.CpG 在载卵清白蛋白的 N-三甲基壳聚糖（TMC）纳米粒中作为免疫调节剂和物理交联剂的双重作用用于鼻腔免疫接种。
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Hypersensitivity and oral tolerance in the absence of a secretory immune system.在缺乏分泌性免疫系统的情况下的过敏反应和口服耐受。
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An established immune response against ovalbumin is suppressed by a transferable serum factor produced after ovalbumin feeding: a role of CD25+ regulatory cells.喂食卵清蛋白后产生的一种可转移血清因子可抑制已建立的针对卵清蛋白的免疫反应：CD25 + 调节性细胞的作用。
Scand J Immunol. 2002 May;55(5):470-7. doi: 10.1046/j.1365-3083.2002.t01-1-01079.x.
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Innate profiles of cytokines implicated on oral tolerance correlate with low- or high-suppression of humoral response.先天细胞因子谱与体液反应的低抑制或高抑制相关，这与口服耐受有关。
Immunology. 2010 Jul;130(3):447-57. doi: 10.1111/j.1365-2567.2010.03248.x. Epub 2010 Mar 16.

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Strategies to Use Nanoparticles to Generate CD4 and CD8 Regulatory T Cells for the Treatment of SLE and Other Autoimmune Diseases.利用纳米颗粒生成 CD4 和 CD8 调节性 T 细胞治疗系统性红斑狼疮和其他自身免疫性疾病的策略。
Front Immunol. 2021 Jun 15;12:681062. doi: 10.3389/fimmu.2021.681062. eCollection 2021.
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Use of Polymeric Nanoparticle Platform Targeting the Liver To Induce Treg-Mediated Antigen-Specific Immune Tolerance in a Pulmonary Allergen Sensitization Model.利用聚合物纳米颗粒平台靶向肝脏诱导调节性 T 细胞介导的抗原特异性免疫耐受在肺变应原致敏模型中。
ACS Nano. 2019 Apr 23;13(4):4778-4794. doi: 10.1021/acsnano.9b01444. Epub 2019 Apr 12.
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Nanoparticles for the Induction of Antigen-Specific Immunological Tolerance.用于诱导抗原特异性免疫耐受的纳米颗粒。
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Chitosan-zein nano-in-microparticles capable of mediating in vivo transgene expression following oral delivery.壳聚糖-玉米醇溶蛋白纳米微球在口服给药后能够介导体内转基因表达。
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本文引用的文献

1
Effective and safe gene-based delivery of GLP-1 using chitosan/plasmid-DNA therapeutic nanocomplexes in an animal model of type 2 diabetes.壳聚糖/质粒 DNA 治疗性纳米复合物在 2 型糖尿病动物模型中有效且安全地传递 GLP-1。
Gene Ther. 2011 Aug;18(8):807-16. doi: 10.1038/gt.2011.25. Epub 2011 Mar 17.
2
Efficacy of the slow dose-up method for specific oral tolerance induction in children with cow's milk allergy: comparison with reported protocols.缓慢剂量递增法诱导牛奶过敏儿童特异性口服耐受的疗效：与报道方案的比较
J Investig Allergol Clin Immunol. 2010;20(6):538-9.
3
Induction of oral tolerance to peanut: a successful home-based protocol.口服花生耐受诱导：一项成功的家庭为基础的方案。
J Investig Allergol Clin Immunol. 2010;20(6):524-8.
4
Intranasal vaccination with chitosan-DNA nanoparticles expressing pneumococcal surface antigen a protects mice against nasopharyngeal colonization by Streptococcus pneumoniae.用表达肺炎球菌表面抗原a的壳聚糖-DNA纳米颗粒进行鼻内接种可保护小鼠免受肺炎链球菌的鼻咽部定植。
Clin Vaccine Immunol. 2011 Jan;18(1):75-81. doi: 10.1128/CVI.00263-10. Epub 2010 Nov 3.
5
Repeated oral administration of chitosan/DNA nanoparticles delivers functional FVIII with the absence of antibodies in hemophilia A mice.壳聚糖/DNA 纳米粒经重复口服给药可递送达血友病 A 小鼠体内具有功能的 FVIII，且无抗体产生。
J Thromb Haemost. 2010 Dec;8(12):2743-50. doi: 10.1111/j.1538-7836.2010.04116.x.
6
A novel recombinant peptide containing only two T-cell tolerance epitopes of chicken type II collagen that suppresses collagen-induced arthritis.一种仅包含鸡Ⅱ型胶原蛋白的两个T细胞耐受表位的新型重组肽，可抑制胶原诱导的关节炎。
Mol Immunol. 2009 Feb;46(4):729-37. doi: 10.1016/j.molimm.2008.10.016. Epub 2008 Nov 28.
7
Expression of human insulin gene wrapped with chitosan nanoparticles in NIH3T3 cells and diabetic rats.壳聚糖纳米粒包裹的人胰岛素基因在NIH3T3细胞和糖尿病大鼠中的表达
Acta Pharmacol Sin. 2008 Nov;29(11):1342-9. doi: 10.1111/j.1745-7254.2008.00888.x.
8
Oral tolerance: intestinal homeostasis and antigen-specific regulatory T cells.口服耐受：肠道稳态与抗原特异性调节性T细胞
Trends Immunol. 2008 Nov;29(11):532-40. doi: 10.1016/j.it.2008.09.002.
9
Gene therapy for type 1 diabetes mellitus in rats by gastrointestinal administration of chitosan nanoparticles containing human insulin gene.通过胃肠道给予含人胰岛素基因的壳聚糖纳米粒对大鼠1型糖尿病进行基因治疗。
World J Gastroenterol. 2008 Jul 14;14(26):4209-15. doi: 10.3748/wjg.14.4209.
10
Gene transfer to hemophilia A mice via oral delivery of FVIII-chitosan nanoparticles.通过口服递送FVIII-壳聚糖纳米颗粒将基因转移至甲型血友病小鼠体内。
J Control Release. 2008 Dec 18;132(3):252-9. doi: 10.1016/j.jconrel.2008.06.019. Epub 2008 Jun 27.

使用壳聚糖-DNA纳米颗粒的口服基因应用可诱导可转移的耐受性。

Oral gene application using chitosan-DNA nanoparticles induces transferable tolerance.

作者信息

Goldmann Katja, Ensminger Stephan M, Spriewald Bernd M

机构信息

Department of Internal Medicine 5-Hematology/Oncology and Institute for Clinical Immunology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.

出版信息

Clin Vaccine Immunol. 2012 Nov;19(11):1758-64. doi: 10.1128/CVI.00186-12. Epub 2012 Aug 29.

DOI:10.1128/CVI.00186-12
PMID:22933401
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3491548/
Abstract

Oral tolerance is a promising approach to induce unresponsiveness to various antigens. The development of tolerogenic vaccines could be exploited in modulating the immune response in autoimmune disease and allograft rejection. In this study, we investigated a nonviral gene transfer strategy for inducing oral tolerance via antigen-encoding chitosan-DNA nanoparticles (NP). Oral application of ovalbumin (OVA)-encoding chitosan-DNA NP (OVA-NP) suppressed the OVA-specific delayed-type hypersensitivity (DTH) response and anti-OVA antibody formation, as well as spleen cell proliferation following OVA stimulation. Cytokine expression patterns following OVA stimulation in vitro showed a shift from a Th1 toward a Th2/Th3 response. The OVA-NP-induced tolerance was transferable from donor to naïve recipient mice via adoptive spleen cell transfer and was mediated by CD4(+)CD25(+) T cells. These findings indicate that nonviral oral gene transfer can induce regulatory T cells for antigen-specific immune modulation.

摘要

口服耐受是一种诱导机体对各种抗原无反应性的有前景的方法。耐受性疫苗的研发可用于调节自身免疫性疾病和同种异体移植排斥反应中的免疫应答。在本研究中，我们研究了一种通过抗原编码壳聚糖 - DNA纳米颗粒（NP）诱导口服耐受的非病毒基因转移策略。口服卵清蛋白（OVA）编码壳聚糖 - DNA NP（OVA - NP）可抑制OVA特异性迟发型超敏反应（DTH）、抗OVA抗体形成以及OVA刺激后的脾细胞增殖。体外OVA刺激后的细胞因子表达模式显示从Th1反应向Th2/Th3反应转变。OVA - NP诱导的耐受性可通过过继性脾细胞转移从供体小鼠转移至未接触过抗原的受体小鼠，并由CD4(+)CD25(+) T细胞介导。这些发现表明非病毒口服基因转移可诱导调节性T细胞进行抗原特异性免疫调节。